Deciphering the Enigma: NAP (CP201) the Active ADNP Drug Candidate Enters Cells by Dynamin-Associated Endocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-020-01632-6
Abstract: NAP (NAPVSIPQ) was identified by screening a cDNA expression library from neuroglial origin with antibodies prepared against activity-dependent neurotrophic factor (ADNF-14/9), which then revealed a new protein to science, activity-dependent neuroprotective protein (ADNP) (Bassan et… read more here.
Keywords: enigma nap; cp201; deciphering enigma; drug candidate ... See more keywords
Interaction of SZV 1287, a novel oxime analgesic drug candidate, and its metabolites with serum albumin
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.115945
Abstract: Abstract SZV 1287 is our novel multi-target analgesic, which seems to be a promising drug candidate for the treatment of neuropathic pain. Therefore, the drug development process has been started in 2016. Since the pharmacokinetic… read more here.
Keywords: serum albumin; interaction; szv 1287; szv ... See more keywords
Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites.
Sign Up to like & getrecommendations! Published in 2023 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00537
Abstract: SQ109 is a tuberculosis drug candidate that has high potency against Mycobacterium tuberculosis and is thought to function at least in part by blocking cell wall biosynthesis by inhibiting the MmpL3 transporter. It also has… read more here.
Keywords: tuberculosis; drug candidate; sq109 bacteria; activity ... See more keywords
Combining the platinum(ii) drug candidate kiteplatin with 1,10-phenanthroline analogues.
Sign Up to like & getrecommendations! Published in 2018 at "Dalton transactions"
DOI: 10.1039/c7dt04108j
Abstract: Platinum complexes of the type [Pt(PL)(AL)]2+ where PL is a derivative of 1,10-phenanthroline and AL is cis-1,4-diaminocyclohexane (1,4-dach), have been synthesised and characterised by ultraviolet spectroscopy, elemental microanalysis, nuclear magnetic resonance and X-ray crystallography. The… read more here.
Keywords: candidate kiteplatin; kiteplatin phenanthroline; drug candidate; phenanthroline ... See more keywords
A sustainable, efficient, and potentially cost-effective approach to the antimalarial drug candidate MMV688533
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc01699d
Abstract: A 6-step synthesis of the antimalarial drug candidate MMV688533 is reported. read more here.
Keywords: candidate mmv688533; antimalarial drug; drug candidate;
Coumarin derivative as a potent drug candidate against triple negative breast cancer targeting the frizzled receptor of wingless-related integration site signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2021.2022536
Abstract: Abstract Triple negative breast cancer constitutes to about 21.8 percent of the total breast cancer related cases. Its ability to affect young ladies and in pre-menstrual stage makes this a disease of concern worldwide. The… read more here.
Keywords: breast cancer; drug candidate; cancer;
Helicase-primase inhibitors from Medshine Discovery Inc. (WO2018/127207 and WO2020/007355) for the treatment of herpes simplex virus infections – structure proposal for Phaeno Therapeutics drug candidate HN0037
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2113873
Abstract: ABSTRACT Helicase-primase is an interesting target for small-molecule therapy of herpes simplex virus (HSV) infections. With amenamevir already approved for varicella-zoster virus and with pritelivir’s granted breakthrough therapy designation for the treatment of acyclovir-resistant HSV… read more here.
Keywords: simplex virus; drug candidate; phaeno therapeutics; helicase primase ... See more keywords
Design and characterization of MP0250, a tri-specific anti-HGF/anti-VEGF DARPin® drug candidate
Sign Up to like & getrecommendations! Published in 2017 at "mAbs"
DOI: 10.1080/19420862.2017.1305529
Abstract: ABSTRACT MP0250 is a multi-domain drug candidate currently being tested in clinical trials for the treatment of cancer. It comprises one anti-vascular endothelial growth factor-A (VEGF-A), one anti-hepatocyte growth factor (HGF), and two anti-human serum… read more here.
Keywords: mp0250; darpin drug; drug candidate; anti ... See more keywords
CMap analysis identifies Atractyloside as a potential drug candidate for type 2 diabetes based on integration of metabolomics and transcriptomics
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15357
Abstract: This research aimed at exploring the mechanisms of alterations of metabolites and pathways in T2D from the perspective of metabolomics and transcriptomics, as well as uncovering novel drug candidate for T2D treatment. read more here.
Keywords: cmap analysis; drug candidate; metabolomics transcriptomics; analysis identifies ... See more keywords
Cebranopadol, a novel first-in-class drug candidate: Method validation and first exploratory pharmacokinetic study in rabbits.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.12948
Abstract: Cebranopadol is a novel, centrally acting, potent, first-in-class analgesic drug candidate with a unique mode of action that combines nociceptin/orphanin FQ peptide receptor and opioid peptide receptor agonism. The present study aimed to develop and… read more here.
Keywords: drug candidate; method; cebranopadol novel; method validation ... See more keywords
GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00132-22
Abstract: As a result of a high-throughput compound screening campaign using Mycobacterium tuberculosis-infected macrophages, a new drug candidate for the treatment of tuberculosis has been identified. GSK2556286 inhibits growth within human macrophages (50% inhibitory concentration [IC50]… read more here.
Keywords: tuberculosis; potential shorten; drug candidate; treatment ... See more keywords