Development of new Alzheimer's disease drug candidates using donepezil as a key model
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200398
Abstract: Alzheimer's disease (AD) is one of the most prevalent geriatric diseases and a significant cause of high mortality. This crippling disorder is becoming more prevalent at an unprecedented rate, which has led to an increase… read more here.
Keywords: development new; disease; alzheimer disease; drug candidates ... See more keywords
Rapid screening of drug candidates against EGFR/HER2 signaling pathway using fluorescence assay
Sign Up to like & getrecommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-1403-1
Abstract: AbstractOver the recent decade, the calcium-based assays have gained much popularity in order to discover new drugs. Since breast cancer is the second cause of death in the female population, rapid and effective methods are… read more here.
Keywords: fluorescence; drug candidates; signaling pathway; egfr her2 ... See more keywords
Molecular basis for drug repurposing to study the interface of the S protein in SARS-CoV-2 and human ACE2 through docking, characterization, and molecular dynamics for natural drug candidates
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-020-04599-8
Abstract: A novel coronavirus (SARS-CoV-2) identified in Wuhan state of China in 2019 is the causative agent of deadly disease COVID-19. It has spread across the globe (more than 210 countries) within a short period. Coronaviruses… read more here.
Keywords: human ace2; drug candidates; protein sars; drug ... See more keywords
Ferrocenes as new anticancer drug candidates: Determination of the mechanism of action.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172825
Abstract: Chemotherapy plays an essential role in the management of cancer worldwide. However, it is a non-specific treatment limited by major drawbacks, thus identification and testing of new promising molecular structures representing potential drug candidates are… read more here.
Keywords: mechanism; drug candidates; new anticancer; ferrocenes new ... See more keywords
Biotransformation of prednisone and dexamethasone by cytochrome P450 based systems - Identification of new potential drug candidates.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2016.12.011
Abstract: Prednisone and dexamethasone are synthetic glucocorticoids widely used as anti-inflammatory and immunosuppressive drugs. Since their hydroxylated derivatives could serve as novel potential drug candidates, our aim was to investigate their biotransformation by the steroid hydroxylase… read more here.
Keywords: prednisone; drug candidates; prednisone dexamethasone; potential drug ... See more keywords
Identification of Endogenous Biomarkers to Predict the Propensity of Drug Candidates to Cause Hepatic or Renal Transporter-Mediated Drug-Drug Interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.04.007
Abstract: Drug transporters expressed in liver and kidney play a critical role in the elimination of a wide range of drugs and xenobiotics and inhibition of these transporters may therefore cause clinically significant drug-drug interactions (DDIs).… read more here.
Keywords: endogenous biomarkers; drug interactions; drug candidates; drug ... See more keywords
Potential Repurposed Drug Candidates for Tuberculosis Treatment: Progress and Update of Drugs Identified in Over a Decade
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c05511
Abstract: The devastating impact of Tuberculosis (TB) has been a menace to mankind for decades. The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to 95% and 90% of overall TB… read more here.
Keywords: progress; drugs identified; repurposed drugs; repurposed drug ... See more keywords
Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-27072-3
Abstract: The main (Mpro) and papain-like (PLpro) proteases encoded by SARS-CoV-2 are essential to process viral polyproteins into functional units, thus representing key targets for anti-viral drug development. There is a need for an efficient inhibitor… read more here.
Keywords: design modular; autoproteolytic gene; drug candidates; drug ... See more keywords
Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41179-0
Abstract: Epitope characterization is critical for elucidating the mechanism of action of drug candidates. However, traditional high-resolution epitope mapping techniques are not well suited for screening numerous drug candidates recognizing a similar target. Here, we use… read more here.
Keywords: drug; hdx epitope; epitope mapping; drug candidates ... See more keywords
Recent advances in iron-complexes as drug candidates for cancer therapy: reactivity, mechanism of action and metabolites.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/d0dt02135k
Abstract: In this perspective, we discuss iron-complexes as drug candidates that are promising alternatives to conventional platinum-based chemotherapies owing to their broad range of reactivities and to the targeting of different biological systems. Breakthroughs in the… read more here.
Keywords: drug candidates; complexes drug; recent advances; iron ... See more keywords
Identification of promising antiviral drug candidates against non-structural protein 15 (NSP15) from SARS-CoV-2: an in silico assisted drug-repurposing study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1814870
Abstract: Abstract The recent COVID-19 pandemic caused by SARS-CoV-2 has recorded a high number of infected people across the globe. The virulent nature of the virus makes it necessary for us to identify promising therapeutic agents… read more here.
Keywords: non structural; drug candidates; sars cov; drug ... See more keywords