Induced Pluripotent Stem Cell-Derived Cardiomyocytes: A Platform for Testing For Drug Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Progress in pediatric cardiology"
DOI: 10.1016/j.ppedcard.2017.07.001
Abstract: Off-target cardiotoxicity has been a significant impediment to the development of new drugs. Traditional platforms for screening for cardiotoxicity are both overly sensitive and limited in their ability to predict cardiotoxicity that is often only… read more here.
Keywords: drug; drug cardiotoxicity; cardiotoxicity; pluripotent stem ... See more keywords
An in silico–in vitro pipeline for drug cardiotoxicity screening identifies ionic pro‐arrhythmia mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15915
Abstract: Before advancing to clinical trials, new drugs are screened for their pro‐arrhythmic potential using a method that is overly conservative and provides limited mechanistic insight. The shortcomings of this approach can lead to the mis‐classification… read more here.
Keywords: pipeline drug; vitro pipeline; drug cardiotoxicity; screening identifies ... See more keywords