Construction of a target MSNs drugcarrier loaded with siRNAGLI1 and siRNASMO aim at hedgehog signal pathway and the pharmacodynamic study of drug-carriers in the treatment of leukemia stem cells.
Sign Up to like & getrecommendations! Published in 2022 at "Drug delivery and translational research"
DOI: 10.1007/s13346-020-00893-3
Abstract: Leukemia stem cells (LSCs) are responsible for leukemia initiation and targeting LSCs is one strategy to treat this disease. This study aims to target LSCs using multi-siRNA loaded antibodies modified with mesoporous silica nanoparticles (MSNs).… read more here.
Keywords: drug; antibody; drug carriers; treatment ... See more keywords
Physicochemical characterization and cytotoxicity of chitosan-modified single walled carbon nanotubes as drug carriers
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-018-0384-6
Abstract: The application of single-walled carbon nanotubes (SWCNTs) as drug carriers is limited by their poor dispersal in aqueous medium. This study aimed to prepare chitosan (CS)-modified SWCNTs (CS-SWCNTs) and to evaluate their physicochemical properties and… read more here.
Keywords: walled carbon; carbon nanotubes; drug; single walled ... See more keywords
Nanoparticles modified by polydopamine: Working as “drug” carriers
Sign Up to like & getrecommendations! Published in 2020 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2020.04.003
Abstract: Inspired by the mechanism of mussel adhesion, polydopamine (PDA), a versatile polymer for surface modification has been discovered. Owing to its unique properties like extraordinary adhesiveness, excellent biocompatibility, mild synthesis requirements, as well as distinctive… read more here.
Keywords: carriers nanoparticles; drug; pda modified; modified nanoparticle ... See more keywords
Using CT scout view to scan illicit drug carriers may reduce radiation exposure.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of forensic and legal medicine"
DOI: 10.1016/j.jflm.2021.102202
Abstract: OBJECTIVE The aim of this study was to present our experience on the evaluation of suspected illicit drug carriers via computerized tomography scout view (CTSV) with analysis of detectability and features such as content, form… read more here.
Keywords: illicit drug; radiation exposure; drug carriers; scout view ... See more keywords
Preparation of photolabile nanoparticles by coumarin-based crosslinker for drug delivery under light irradiation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Physics and Chemistry of Solids"
DOI: 10.1016/j.jpcs.2021.110102
Abstract: Abstract Doxorubicin is (DOX) a hydrophobic cancer drug which can be encapsulated inside polymeric drug carriers to grant a prolonged circulation of DOX in blood. Moreover, sufficient stability of drug nanocarriers during their circulation time… read more here.
Keywords: drug; drug carriers; drug delivery; drug release ... See more keywords
Cyclodextrin polymers: Structure, synthesis, and use as drug carriers
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Polymer Science"
DOI: 10.1016/j.progpolymsci.2021.101408
Abstract: Abstract Cyclodextrin-based polymers (CDPs) are amphiphilic macromolecules owing to their unique structure and the presence of multiple hydroxyl groups. These polymers have become increasingly popular in applications ranging from biomedicine to environmental science. In this… read more here.
Keywords: cyclodextrin polymers; drug; drug carriers; structure ... See more keywords
Dual Biochemically Breakable Drug Carriers from Programmed Telechelic Homopolymers.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c01113
Abstract: Well-defined hydrophilic telechelic dibromo poly(triethyleneglycol monomethyl ether acrylate)s were prepared by single-electron transfer living radical polymerization employing a hydrophobic difunctional initiator containing acetal and disulfide linkages. Despite the resulting homopolymers contain small hydrophobic contents (<… read more here.
Keywords: breakable drug; biochemically breakable; drug; dual biochemically ... See more keywords
Oxidative Stress Amplifying Polyprodrug Micelles as Drug Carriers for Combination Anticancer Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00700
Abstract: Cancer cells are more vulnerable to reactive oxygen species (ROS)-mediated oxidative stress than normal cells due to disturbed redox balance. It can be postulated that ROS-generating drug carriers exert anticancer actions, leading to combination anticancer… read more here.
Keywords: drug carriers; oxidative stress; anticancer therapy; combination anticancer ... See more keywords
Ionic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-70900-7
Abstract: The present study proposes a simple yet effective method of cellulose coating onto chitosan (CS) hydrogel beads and application thereof as drug carriers. The beads were coated with cellulose dissolved in 1-ethyl-3-methylimidazolium acetate, an ionic… read more here.
Keywords: beads application; drug; hydrogel beads; chitosan hydrogel ... See more keywords
Predicting the impact of structural diversity on the performance of nanodiamond drug carriers.
Sign Up to like & getrecommendations! Published in 2018 at "Nanoscale"
DOI: 10.1039/c8nr01688g
Abstract: Diamond nanoparticles (nanodiamonds) are unique among carbon nanomaterials, and are quickly establishing a niché in the biomedical application domain. Nanodiamonds are non-toxic, amenable to economically viable mass production, and can be interfaced with a variety… read more here.
Keywords: performance nanodiamond; diversity; structural diversity; nanodiamond drug ... See more keywords
Recent progress in nanotechnology-based drug carriers for celastrol delivery.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d1bm00639h
Abstract: Celastrol (CLT) is an active ingredient that was initially discovered and extracted from the root of Tripterygium wilfordii. The potential pharmacological activities of CLT in cancer, obesity, and inflammatory, auto-immune, and neurodegenerative diseases have been… read more here.
Keywords: progress nanotechnology; nanotechnology; recent progress; nanotechnology based ... See more keywords