Humans are animals, but are animals human enough? A systematic review and meta-analysis on interspecies differences in renal drug clearance.
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DOI: 10.1016/j.drudis.2020.01.018
Abstract: Various animal models are used to study pharmacokinetics (PK) of drugs in development. Human renal clearance (CLr) should be predictable through interpolation from animal data by allometric scaling. Based on this premise, we quantified interspecies… read more here.
Keywords: drug clearance; drug; interspecies differences; clearance ... See more keywords
A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice
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DOI: 10.1186/s12936-019-2860-5
Abstract: BackgroundGiven the central importance of anti-malarial drugs in the treatment of malaria, there is a need to understand the effect of Plasmodium infection on the broad spectrum of drug metabolizing enzymes. Previous studies have shown… read more here.
Keywords: drug metabolizing; drug clearance; infection; drug ... See more keywords