Abstract 6573: Drug Combo: A unique resource for efficient phase 1 trial design with manually curated MTD and DLT
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6573
Abstract: Background: With prior preclinical and clinical knowledge, an effective and efficient cancer drug combinatory trial design could be expected, which will significantly accelerate the translation. However, our internal survey results suggested that some knowledge and… read more here.
Keywords: curated mtd; trial; mtd dlt; drug ... See more keywords
Drug Combo Bests Sunitinib in RCC.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2018-023
Abstract: The phase III IMmotion151 trial found that the combination of atezolizumab and bevacizumab boosts progression-free survival compared with sunitinib in patients with advanced or metastatic renal cell carcinoma. The increase was 2.8 months in all… read more here.
Keywords: drug combo; sunitinib rcc; bests sunitinib; combo bests ... See more keywords
Drug Combo May Obviate Chemotherapy in ALL.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2020-99
Abstract: A phase II trial shows that a chemotherapy-free regimen of dasatinib and blinatumomab produces molecular responses in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. The study found that 60% of patients had molecular responses after… read more here.
Keywords: molecular responses; combo may; obviate chemotherapy; may obviate ... See more keywords