A comparison of covariate selection techniques applied to pre-exposure prophylaxis (PrEP) drug concentration data in men and transgender women at risk for HIV.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacokinetics and pharmacodynamics"
DOI: 10.1007/s10928-021-09763-y
Abstract: Pre-exposure prophylaxis (PrEP) containing antiretrovirals tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide (TAF) can reduce the risk of acquiring HIV. Concentrations of intracellular tenofovir-diphosphate (TFV-DP) measured in dried blood spots (DBS) have been used to… read more here.
Keywords: exposure prophylaxis; drug concentration; selection; pre exposure ... See more keywords
Amlodipine alters hemorheological parameters: Increased efficacy at the cost of edema?
Sign Up to like & getrecommendations! Published in 2019 at "Indian Heart Journal"
DOI: 10.1016/j.ihj.2018.10.417
Abstract: Background Despite several decades of use of calcium channel blockers, the side effect of edema persists as a class effect, and its mechanism is unresolved. Amlodipine has effects on hemorheology (HR), and its hemodilutory property… read more here.
Keywords: shear rates; drug; amlodipine alters; edema ... See more keywords
Engineered Bioluminescent Indicator Enables the Brain Imaging of Kinase Inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.3c00367
Abstract: With the emergence of an aging society, brain diseases such as brain tumors, Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke account for an increasing proportion of global diseases, resulting in a growing demand for… read more here.
Keywords: drug concentration; brain; kinase; drug development ... See more keywords
Efficient Tumor Eradication at Ultralow Drug Concentration via Externally Controlled and Boosted Metallic Iron Magnetoplasmonic Nanocapsules
Sign Up to like & getrecommendations! Published in 2022 at "ACS Nano"
DOI: 10.1021/acsnano.2c05733
Abstract: With the aim to locally enhance the efficacy of cancer nanotherapies, here we present metal iron based magnetoplasmonic drug-loaded nanocapsules (MAPSULES), merging powerful external magnetic concentration in the tumor and efficient photothermal actuation to locally… read more here.
Keywords: drug concentration; iron; ultralow drug; drug ... See more keywords
Antifungal Drug Concentration Impacts the Spectrum of Adaptive Mutations in Candida albicans
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad009
Abstract: Abstract Invasive fungal infections are a leading global cause of human mortality. Only three major classes of antifungal drugs are widely used, and resistance to all three classes can arise rapidly. The most widely prescribed… read more here.
Keywords: drug concentration; concentration impacts; antifungal drug; drug ... See more keywords
Tissue Drug Concentration.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666220422091159
Abstract: Blood flow enables the delivery of oxygen and nutrients to the different tissues of the human body. Drugs follow the same route as oxygen and nutrients; thus, drug concentrations in tissues are highly dependent on… read more here.
Keywords: drug concentration; concentration; drug; blood flow ... See more keywords
Development and application of a urine drug concentration method for the evaluation of oral absorption of ibandronate in clinical patients.
Sign Up to like & getrecommendations! Published in 2019 at "Bioanalysis"
DOI: 10.4155/bio-2018-0223
Abstract: Aim: A urine drug concentration method was developed for the evaluation of oral ibandronte absorption based on the fact that ibandronate is excreted unchanged by the kidneys. Methodology: Ibandronate was isolated from the urine matrix… read more here.
Keywords: absorption; concentration method; evaluation oral; method ... See more keywords
Bioequivalence of cyclobenzaprine hydrochloride extended-release capsule taken intact or sprinkled over applesauce .
Sign Up to like & getrecommendations! Published in 2017 at "International journal of clinical pharmacology and therapeutics"
DOI: 10.5414/cp203059
Abstract: OBJECTIVE Difficulty swallowing pills can compromise pain control in painful musculoskeletal disorders. This open-label, 2-period crossover study assessed pharmacokinetics and safety of cyclobenzaprine extended-release (CER) 30-mg capsule contents sprinkled over applesauce compared with intact capsules… read more here.
Keywords: drug concentration; capsule; cer; sprinkled applesauce ... See more keywords