Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.
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DOI: 10.1021/acsmedchemlett.1c00048
Abstract: An unbiased phenotypic neuronal assay was developed to measure the synaptotoxic effects of soluble Aβ oligomers. A collection of CNS druglike small molecules prepared by conditioned extraction was screened. Compounds that prevented and reversed synaptotoxic… read more here.
Keywords: drug ct1812; investigational drug; alzheimer disease; receptor complex ... See more keywords