In silico analysis of the effect of mutation on epidermal growth factor receptor in non-small-cell lung carcinoma: from mutational analysis to drug designing
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2016.1146165
Abstract: Tyrosine kinase inhibitors (TKI)-resistant mutation in epidermal growth factor receptor’s (EGFR) kinase domain is an important anomaly to look into. Studying the mutations at atomic level using molecular dynamics simulations gave us an insight into… read more here.
Keywords: drug designing; mutation epidermal; analysis; factor receptor ... See more keywords
Updates on drug designing approach through computational strategies: a review
Sign Up to like & getrecommendations! Published in 2023 at "Future Science OA"
DOI: 10.2144/fsoa-2022-0085
Abstract: The drug discovery and development (DDD) process in pursuit of novel drug candidates is a challenging procedure requiring lots of time and resources. Therefore, computer-aided drug design (CADD) methodologies are used extensively to promote proficiency… read more here.
Keywords: drug designing; updates drug; computational strategies; designing approach ... See more keywords
Molecular Docking: Challenges, Advances and its Use in Drug Discovery Perspective.
Sign Up to like & getrecommendations! Published in 2019 at "Current drug targets"
DOI: 10.2174/1389450119666181022153016
Abstract: Molecular docking is a process through which small molecules are docked into the macromolecular structures for scoring its complementary values at the binding sites. It is a vibrant research area with dynamic utility in structure-based… read more here.
Keywords: advances use; drug designing; drug; challenges advances ... See more keywords
Exploration of Computational Aids for Effective Drug Designing and Management of Viral Diseases: A Comprehensive Review.
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DOI: 10.2174/1568026623666230201144522
Abstract: BACKGROUND Microbial diseases, specifically originating from viruses are the major cause of human mortality all over the world. The current COVID-19 pandemic is a case in point, where the dynamics of the viral-human interactions are… read more here.
Keywords: drug designing; effective drug; review; management ... See more keywords
Computational Drug Designing and Prediction Of Important Parameters Using in silico Methods- A Review.
Sign Up to like & getrecommendations! Published in 2019 at "Current computer-aided drug design"
DOI: 10.2174/1573399815666190326120006
Abstract: BACKGROUND Computational or in silico studies are undertaken to assess the drug like properties of lead compounds. These studies help in fast prediction of relevant properties. OBJECTIVE Through this review an effort is made to… read more here.
Keywords: designing prediction; drug designing; drug; computational drug ... See more keywords