Costs of Drug Development and Research and Development Intensity in the US, 2000-2018
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.15445
Abstract: Key Points Question What is the mean cost of drug development for the US market, and how has research and development (R&D) intensity changed over time? Findings This economic evaluation study used data from public… read more here.
Keywords: 2000 2018; development intensity; research development; drug development ... See more keywords
The Next Wave After Immunotherapy in Cancer Drug Development-Back to the Future.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2025.0720
Abstract: This Viewpoint discusses the history of immunotherapy and the future of targeted therapy to treat cancer. read more here.
Keywords: cancer; next wave; immunotherapy cancer; cancer drug ... See more keywords
New clinical trial designs in the era of precision medicine
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12465
Abstract: Cancer treatment has made significant strides towards the promise of personalized medicine. Recent scientific advances have shown that there are numerous genetic deregulations that are common in multiple cancer types, raising the possibility of developing… read more here.
Keywords: medicine; drug development; trial designs; oncology ... See more keywords
Acute myeloid leukemia drug development in the post‐venetoclax era
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25556
Abstract: Much has been written and discussed related to the recent plethora of drug approvals by the United States Food and Drug Administration (FDA) for acute myeloid leukemia (AML). This topic has been met with appropriate… read more here.
Keywords: drug development; venetoclax; myeloid leukemia; drug ... See more keywords
Drug re‐engineering and repurposing: A significant and rapid approach to tuberculosis drug discovery
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200214
Abstract: The prevalence of tuberculosis (TB) remains the leading cause of death from a single infectious agent, ranking it above all other contagious diseases. The problem to tackle this disease seems to become even worse due… read more here.
Keywords: drug discovery; tuberculosis; classes compounds; drug development ... See more keywords
Changing incentives to ACCELERATE drug development for paediatric cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5627
Abstract: More effective incentives are needed to motivate paediatric oncology drug development, uncoupling it from dependency on adult drug development. Although the current European and North‐American legislations aim to promote drug development for paediatrics and rare… read more here.
Keywords: changing incentives; drug development; cancer; incentives accelerate ... See more keywords
Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)‐[11C]YH132: Application in Drug Development and Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202300819
Abstract: Monoacylglycerol lipase (MAGL) plays a crucial role in the degradation of 2‐arachidonoylglycerol (2‐AG), one of the major endocannabinoids in the brain. Inhibiting MAGL could lead to increased levels of 2‐AG, which showed beneficial effects on… read more here.
Keywords: 11c yh132; pet tracer; monoacylglycerol lipase; drug development ... See more keywords
Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 and Covid‐19
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200440
Abstract: COVID‐19, caused by SARS‐CoV‐2 infection, continues to be a major public health crisis around the globe. Development of vaccines and the first cluster of antiviral drugs has brought promise and hope for prevention and treatment… read more here.
Keywords: development; chemistry; treatment; drug development ... See more keywords
Bridging Efficacy of Tofacitinib Immediate‐Release to Extended‐Release Formulations for Treatment of Ulcerative Colitis: Application of a Model‐Informed Drug Development Approach
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1106
Abstract: Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). We report a model‐informed drug development approach for bridging efficacy from immediate‐release (IR) to extended‐release (XR) tofacitinib formulations in… read more here.
Keywords: tofacitinib; efficacy; release; drug development ... See more keywords
Dosing Recommendation Based on the Effects of Different Meal Types on Pexidartinib Pharmacokinetics in Healthy Subjects: Implementation of Model‐informed Drug Development Strategy
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1240
Abstract: Pexidartinib, an oral small molecule inhibitor of the colony‐stimulating factor 1 receptor, is approved for treatment of adults with symptomatic tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to… read more here.
Keywords: meal; low fat; dosing regimen; fat meal ... See more keywords
Model‐Informed Drug Development for Long‐Acting Injectable Products: Summary of American College of Clinical Pharmacology Symposium
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.928
Abstract: Poor adherence to prescribed medications significantly impacts the U.S. health care system.1–4 Given the human and financial consequences, the development of strategies for improving adherence to prescribed medications is imperative. Long-acting injectable (LAI) drug products… read more here.
Keywords: drug development; long acting; drug; pharmacology ... See more keywords