Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2558
Abstract: Mathematical models, such as physiologically‐based pharmacokinetic models, are used to predict, for example, drug disposition and toxicity. However, populations differ in the abundance of proteins involved in these processes. To improve the building and refinement… read more here.
Keywords: liver; jejunum; pharmacology; drug disposition ... See more keywords
Recent advance in the pharmacogenomics of human Solute Carrier Transporters (SLCs) in drug disposition☆
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Drug Delivery Reviews"
DOI: 10.1016/j.addr.2016.06.004
Abstract: &NA; Drug pharmacokinetics is influenced by the function of metabolising enzymes and influx/efflux transporters. Genetic variability of these genes is known to impact on clinical therapies. Solute Carrier Transporters (SLCs) are the primary influx transporters… read more here.
Keywords: recent advance; carrier transporters; solute carrier; drug ... See more keywords
Epigenetics in drug disposition & drug therapy: symposium report of the 24th North American meeting of the International Society for the Study of Xenobiotics (ISSX)
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2022.2101662
Abstract: Abstract The 24th North American International Society for the Study of Xenobiotics (ISSX) meeting, held virtually from September 13 to 17, 2021, embraced the theme of “Broadening Our Horizons.” This reinforces a key mission of… read more here.
Keywords: disposition drug; epigenetics drug; 24th north; drug disposition ... See more keywords
Target‐mediated drug disposition modeling of an anti‐TFPI antibody (MG1113) in cynomolgus monkeys to predict human pharmacokinetics and pharmacodynamics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15244
Abstract: MG1113 is a human monoclonal antibody of tissue factor pathway inhibitor (TFPI) under development for prophylaxis for hemophilia patients with or without inhibitors against factor VIII products, which have been used for the treatment of… read more here.
Keywords: disposition modeling; antibody; mediated drug; tfpi ... See more keywords
Appreciating the need for greater understanding of the pharmacokinetics of drugs in children and adolescents
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Transplantation"
DOI: 10.1111/petr.13312
Abstract: Most immunosuppressants are critical dose drugs with a narrow ther‐ apeutic index.1 While pharmacokinetic monitoring is well‐established and always accompanies the phase I‐III studies of new immunosup‐ pressants or formulations in adult solid organ transplantation,… read more here.
Keywords: drug; transplantation; appreciating need; greater understanding ... See more keywords
Abstract A25: Evaluation of Drug Disposition in Supratentorial Ependymoma
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DOI: 10.1158/1538-7445.pedca19-a25
Abstract: Introduction: The majority of pediatric supratentorial (ST) ependymomas (EPN) is driven by distinct gene fusions between C11orf95 and RELA. The resultant molecular group of ST-EPN-RELA tumors is characterized by constitutive activation of NF-κB signaling and… read more here.
Keywords: drug; epn rela; evaluation drug; drug disposition ... See more keywords
Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring
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DOI: 10.3390/pharmaceutics13020161
Abstract: The increasing prevalence of colonic diseases calls for a better understanding of the various colonic drug absorption barriers of colon-targeted formulations, and for reliable in vitro tools that accurately predict local drug disposition. In vivo… read more here.
Keywords: lower gastrointestinal; drug; physiology; disposition lower ... See more keywords