NRBdMF: A recommendation algorithm for predicting drug effects considering directionality
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01210
Abstract: Predicting the novel effects of drugs based on information about approved drugs can be regarded as a recommendation system. Matrix factorization is one of the most used recommendation systems, and various algorithms have been devised… read more here.
Keywords: matrix; predicting drug; recommendation; drug effects ... See more keywords
Mimicking multi-organ drug effects
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Cancer"
DOI: 10.1038/s41568-019-0175-z
Abstract: McAleer, Long et al. generated a reconfigurable body-on-a-chip system with recirculating medium to analyse organ function in response to anticancer drugs in real-time, which can help to improve preclinical drug testing. read more here.
Keywords: drug; drug effects; mimicking multi; multi organ ... See more keywords
Multi-parametric characterization of drug effects on cells.
Sign Up to like & getrecommendations! Published in 2020 at "F1000Research"
DOI: 10.12688/f1000research.26254.1
Abstract: We present here a novel multi-parametric approach for the characterization of multiple cellular features, using images acquired by high-throughput and high-definition light microscopy. We specifically used this approach for deep and unbiased analysis of the… read more here.
Keywords: drug; parametric characterization; drug effects; multi parametric ... See more keywords
Unifying Theories of Psychedelic Drug Effects
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00172
Abstract: How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of psychedelic-assisted therapies? Efforts to understand psychedelic… read more here.
Keywords: psychedelic drug; unifying theories; theories psychedelic; century ... See more keywords
A Cell Double-Barcoding System for Quantitative Evaluation of Primary Tumors and Metastasis in Animals That Uncovers Clonal-Specific Anti-Cancer Drug Effects
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14061381
Abstract: Simple Summary The main problem in treating advanced cancers is a metastatic spread when individual cancer cells leave the primary tumor and colonize to distant organs. In drug development, it is important to quantitatively assess… read more here.
Keywords: system; cell; drug effects; tumors metastasis ... See more keywords