Multi-scale modeling of drug binding kinetics to predict drug efficacy
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03376-y
Abstract: Optimizing drug therapies for any disease requires a solid understanding of pharmacokinetics (the drug concentration at a given time point in different body compartments) and pharmacodynamics (the effect a drug has at a given concentration).… read more here.
Keywords: drug binding; drug; binding kinetics; drug efficacy ... See more keywords
Field evaluation of anticoccidial efficacy: A novel approach demonstrates reduced efficacy of toltrazuril against ovine Eimeria spp. in Norway
Sign Up to like & getrecommendations! Published in 2018 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2018.05.002
Abstract: Ovine Eimeria spp. infections cause reduced welfare, increased mortality, and substantial economic losses, and anticoccidials are crucial for their control. Recent reports of toltrazuril resistance in pigs, and anecdotal reports of reduced anticoccidial efficacy in… read more here.
Keywords: ovine eimeria; efficacy; drug efficacy; eimeria spp ... See more keywords
Drug efficacy on zoonotic nematodes of the Anisakidae family: new metabolic data
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology"
DOI: 10.1017/s0031182022000543
Abstract: Abstract Abstract In the Anisakidae family, there are nematodes, most of which are parasitic for important commercial fish species. Both public health risks and socio-economic problems are attributed to these parasites. Despite these concerns, knowledge… read more here.
Keywords: family; efficacy zoonotic; zoonotic nematodes; nematodes anisakidae ... See more keywords
HIDEEP: a systems approach to predict hormone impacts on drug efficacy based on effect paths
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16855-8
Abstract: Experimental evidence has shown that some of the human endogenous hormones significantly affect drug efficacy. Since hormone status varies with individual physiological states, it is essential to understand the interplay of hormones and drugs for… read more here.
Keywords: drug; drug efficacy; effect paths; hormone ... See more keywords
A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs–monitoring of therapeutic drug efficacy as a case study
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Neglected Tropical Diseases"
DOI: 10.1101/2023.01.06.23284253
Abstract: Background: Soil-transmitted helminth (STH) control programs currently lack evidence-based recommendations for cost-efficient survey designs for monitoring and evaluation. Here, we present a framework to provide evidence-based recommendations, using a case study of therapeutic drug efficacy… read more here.
Keywords: cost; therapeutic drug; survey; drug efficacy ... See more keywords
Spatiotemporal Heterogeneity across Metastases and Organ-Specific Response Informs Drug Efficacy and Patient Survival in Colorectal Cancer
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DOI: 10.1158/0008-5472.can-20-3665
Abstract: These findings support the modification of RECIST criteria to include individual lesion response to improve assessments of drug efficacy. The sum of target lesions is routinely used to evaluate patient objective responses to treatment in… read more here.
Keywords: heterogeneity across; drug efficacy; response; heterogeneity ... See more keywords
Emergence of spatio-temporal variations in chemotherapeutic drug efficacy: in-vitro and in-Silico 3D tumour spheroid studies
Sign Up to like & getrecommendations! Published in 2020 at "BMC Cancer"
DOI: 10.1186/s12885-020-07677-5
Abstract: Background The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. We explore the… read more here.
Keywords: spatio temporal; efficacy; drug; drug efficacy ... See more keywords