A Transcriptomic Approach to Identify Novel Drug Efflux Pumps in Bacteria.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7454-2_12
Abstract: The core genomes of most bacterial species include a large number of genes encoding putative efflux pumps. The functional roles of most of these pumps are unknown, however, they are often under tight regulatory control… read more here.
Keywords: novel drug; identify novel; drug efflux; efflux pumps ... See more keywords
Structure-property correlation in gallic acid and 4-cyanopyridine cocrystal and binding studies with drug efflux pump in bacteria
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.129279
Abstract: Abstract This work focuses on the self-assembled gallic acid (GA) and 4-cyanopyridine (4-CNpy) (1:1) adduct, GA-CNpy (1), constructed from various non-covalent interactions. The cocrystal was characterized by X-ray crystallography, FT-IR and NMR spectroscopy. In the… read more here.
Keywords: gallic acid; efflux pump; acid cyanopyridine; drug efflux ... See more keywords
An Enzyme-Directed Imidazoquinoline Activated by Drug Resistance.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00095
Abstract: Drug efflux and enzymatic drug degradation are two cellular mechanisms that contribute to drug resistance in many cancers. Herein, we report the synthesis and in vitro activity of a pro-immunostimulant that exploits both processes in… read more here.
Keywords: drug; drug resistance; drug efflux; enzyme directed ... See more keywords
Simulated Drug Efflux for the AbgT Family of Membrane Transporters.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00516
Abstract: Drug extrusion through molecular efflux pumps is an important mechanism for the survival of many pathogenic bacteria by removing drugs, providing multidrug resistance (MDR). Understanding molecular mechanisms for drug extrusion in multidrug efflux pumps is… read more here.
Keywords: abgt family; drug; drug efflux; efflux ... See more keywords
Synthesis and Preclinical Positron Emission Tomography Imaging of the p38 MAPK Inhibitor [11C]Talmapimod: Effects of Drug Efflux and Sex Differences.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00205
Abstract: Stress-activated kinases are targets of interest in neurodegenerative disease due to their involvement in inflammatory signaling and synaptic dysfunction. The p38α kinase has shown clinical and preclinical promise as a druggable target in several neurodegenerative… read more here.
Keywords: 11c talmapimod; brain; inhibitor; sex ... See more keywords
Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18948-w
Abstract: Disulfides from Allium stipitatum, commonly known as Persian shallot, were previously reported to possess antibacterial properties. Analogues of these compounds, produced by S-methylthiolation of appropriate thiols using S-methyl methanethiosulfonate, exhibited antimicrobial activity, with one compound… read more here.
Keywords: inhibition; drug; biofilm; drug efflux ... See more keywords
Direct visualisation of drug-efflux in live Escherichia coli cells.
Sign Up to like & getrecommendations! Published in 2020 at "FEMS microbiology reviews"
DOI: 10.1093/femsre/fuaa031
Abstract: Drug-efflux by pump proteins is one of the major mechanisms of antibiotic resistance in bacteria. Here, we use quantitative fluorescence microscopy to investigate the real-time dynamics of drug accumulation and efflux in live E. coli… read more here.
Keywords: coli cells; efflux pump; drug; efflux live ... See more keywords
Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-019-0559-y
Abstract: BackgroundMultidrug resistance (MDR) is a pressing obstacle in clinical chemotherapy for breast cancer. Based on the fact that the drug efflux is an important factor in MDR, we designed a codelivery system to guide the… read more here.
Keywords: cancer; drug efflux; breast cancer;
Determination of Drug Efflux Pump Efficiency in Drug-Resistant Bacteria Using MALDI-TOF MS
Sign Up to like & getrecommendations! Published in 2020 at "Antibiotics"
DOI: 10.3390/antibiotics9100639
Abstract: Multidrug efflux pumps play an essential role in antibiotic resistance. The conventional methods, including minimum inhibitory concentration and fluorescent assays, to monitor transporter efflux activity might have some drawbacks, such as indirect evidence or interference… read more here.
Keywords: maldi tof; acrb; drug; drug efflux ... See more keywords
In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Fungi"
DOI: 10.3390/jof9020240
Abstract: Mitochondrial dysfunction or morphological abnormalities in human pathogenic fungi are known to contribute to azole resistance; however, the underlying molecular mechanisms are unknown. In this study, we investigated the link between mitochondrial morphology and azole… read more here.
Keywords: gem1; drug efflux; mitochondrial morphology; azole resistance ... See more keywords
Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14061131
Abstract: Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the intestinal lumen, which could lead to extremely poor absorption of drugs by oral administration. Typical… read more here.
Keywords: oral drug; drug efflux; intestinal drug; drug ... See more keywords