Antiretroviral drug exposure in lymph nodes is heterogeneous and drug dependent
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25895
Abstract: HIV reservoirs and infected cells may persist in tissues with low concentrations of antiretrovirals (ARVs). Traditional pharmacology methods cannot assess variability in ARV concentrations within morphologically complex tissues, such as lymph nodes (LNs). We evaluated… read more here.
Keywords: drug exposure; nodes heterogeneous; drug; exposure lymph ... See more keywords
Drug exposure and the risk of multiple sclerosis: A systematic review
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4357
Abstract: Several environmental and lifestyle factors have been associated with multiple sclerosis (MS) risk, including some pharmacological treatments. We systematically reviewed the literature on prescription drug exposure and MS risk. read more here.
Keywords: risk; drug exposure; exposure risk; drug ... See more keywords
Adolescent drug exposure: A review of evidence for the development of persistent changes in brain function
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.01.007
Abstract: Over the past decade, many studies have indicated that adolescence is a critical period of brain development and maturation. The refinement and maturation of the central nervous system over this prolonged period, however, makes the… read more here.
Keywords: drug exposure; exposure; exposure review; brain ... See more keywords
Method performance and clinical workflow outcomes associated with meconium and umbilical cord toxicology testing.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2017.09.016
Abstract: OBJECTIVE Neonatal abstinence syndrome (NAS) is a rising concern with unknown long-term effects. It is apparent that higher cost of care, impact on the community and reduced quality of life are associated with similar etiologies… read more here.
Keywords: umbilical cord; uct; drug exposure; meconium ... See more keywords
Drug exposure may have a substantial influence on COVID-19 prognosis among residents of long-term care facilities: an exploratory analysis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2021.07.007
Abstract: Objectives To explore the association between drug exposure and SARS-CoV-2 prognosis among elderly living in long-term care facilities (LTC) Design We carried out a cross-sectional study among old people living in LTC which had a… read more here.
Keywords: long term; drug exposure; drug; term care ... See more keywords
Ascarids exposed: a method for in vitro drug exposure and gene expression analysis of anthelmintic naïve Parascaris spp
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology"
DOI: 10.1017/s0031182020000189
Abstract: Abstract Ascarid parasites infect a variety of hosts and regular anthelmintic treatment is recommended for all species. Parascaris spp. is the only ascarid species with widespread anthelmintic resistance, which allows for the study of resistance… read more here.
Keywords: drug exposure; vitro drug; drug; parascaris spp ... See more keywords
Poly(lactic acid)-hyperbranched polyglycerol nanoparticles enhance bioadhesive treatment of esophageal disease and reduce systemic drug exposure.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr01846b
Abstract: The effective treatment of esophageal disease represents a significant unmet clinical need, as existing treatments often lead to unnecessary systemic drug exposure and suboptimal concentrations at the disease site. Here, surface-modified bioadhesive poly(lactic acid)-hyperbranched polyglycerol… read more here.
Keywords: drug exposure; systemic drug; drug; treatment esophageal ... See more keywords
Drug Exposure and Effects in Pregnancy and Lactation.
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000732
Abstract: This issue contains articles that focus on the potential adverse effects of fetal and infant drug exposure, which result from maternal drug use during pregnancy and lactation. The issues discussed are part of what could… read more here.
Keywords: drug exposure; pregnancy lactation; drug; act ... See more keywords
Re: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000765
Abstract: available at http://www.ncbi.nlm.nih.gov/pubmed/31233095 Editorial Comment: The potential risk of short-term cognitive side effects of anticholinergics is well known and can be particularly problematic in geriatric patients. However, the long-term effects of these medications on cognition… read more here.
Keywords: drug exposure; case control; risk; dementia ... See more keywords
Does the Tacrolimus Trough Level Adequately Predict Drug Exposure in Patients Requiring a High Tacrolimus Dose?
Sign Up to like & getrecommendations! Published in 2023 at "Transplantation Direct"
DOI: 10.1097/txd.0000000000001439
Abstract: Background. Tacrolimus (Tac) has a narrow therapeutic range. Dosing is generally targeted at Tac trough levels (C0), notwithstanding conflicting reports on the correlation between Tac C0 and systemic exposure measured by the area-under-the-concentration-over-time curve (AUC).… read more here.
Keywords: dose; drug exposure; tac dose; tacrolimus ... See more keywords
Drug exposure and clinical effect of transdermal mirtazapine in healthy young cats: a pilot study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x16667168
Abstract: Objectives The objective of this study was to measure drug exposure and clinical effects after administration of transdermal mirtazapine (TMZ) in healthy cats. Methods Phase I: seven healthy research cats received (1) 3.75 mg and… read more here.
Keywords: transdermal mirtazapine; exposure clinical; drug exposure; mirtazapine ... See more keywords