The design of peptide‐amphiphiles as functional ligands for liposomal anticancer drug and gene delivery
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Drug Delivery Reviews"
DOI: 10.1016/j.addr.2016.08.005
Abstract: Abstract Liposomal nanomedicine has led to clinically useful cancer therapeutics like Doxil and DaunoXome. In addition, peptide‐functionalized liposomes represent an effective drug and gene delivery vehicle with increased cancer cell specificity, enhanced tumor‐penetrating ability and… read more here.
Keywords: drug gene; delivery; drug; gene delivery ... See more keywords
Drug repurposing by integrated literature mining and drug-gene-disease triangulation.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2016.10.008
Abstract: Drug design is expensive, time-consuming and becoming increasingly complicated. Computational approaches for inferring potentially new purposes of existing drugs, referred to as drug repositioning, play an increasingly important part in current pharmaceutical studies. Here, we… read more here.
Keywords: literature mining; disease triangulation; drug gene; drug ... See more keywords
Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2017.04.002
Abstract: Here, we discuss the biomedical applications of graphene-based nanomaterials (GBNs). We examine graphene and its various derivatives, including graphene, graphene oxides (GOs), reduced graphene oxides (rGOs), graphene quantum dots (GQDs), and graphene composites, and discuss… read more here.
Keywords: graphene based; drug gene; graphene; drug ... See more keywords
Predicting Potential Drug-Drug-Gene Interactions in a Population of Individuals Utilizing a Community-Based Pharmacy
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DOI: 10.1017/s1092852922000372
Abstract: Abstract Introduction Adverse drug reactions (ADRs) are associated with increased morbidity, mortality, and resource utilization. Drug interactions (DDIs) are among the most common causes of ADRs, and estimates have cited that up to 22% of… read more here.
Keywords: potential drug; drug gene; drug drug; gene interactions ... See more keywords
Dendritic-Linear Copolymer and Dendron Lipid Nanoparticles for Drug and Gene Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00128
Abstract: Polymers constitute a diverse class of macromolecules that have demonstrated their unique advantages to be utilized for drug or gene delivery applications. In particular, polymers with a highly ordered, hyperbranched structure─"dendrons"─offer significant benefits to the… read more here.
Keywords: drug gene; dendron lipid; drug; gene delivery ... See more keywords
Nanogel Functionalization: A Versatile Approach To Meet the Challenges of Drug and Gene Delivery
Sign Up to like & getrecommendations! Published in 2018 at "ACS Applied Nano Materials"
DOI: 10.1021/acsanm.8b01686
Abstract: The design of nanostructures carrying therapeutic molecules represents the new frontier in the biological and medical fields. In particular, researchers have identified nanogels as promising tools in response to the critical issues of intracellular delivery:… read more here.
Keywords: drug gene; functionalization; gene delivery; delivery ... See more keywords
Gold nanoparticles: current and upcoming biomedical applications in sensing, drug, and gene delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04826d
Abstract: Gold nanoparticles (AuNPs) present unique physicochemical characteristics, low cytotoxicity, chemical stability, size/morphology tunability, surface functionalization capability, and optical properties which can be exploited for detection applications (colorimetry, surface-enhanced Raman scattering, and photoluminescence). The current challenge… read more here.
Keywords: gene delivery; gold nanoparticles; drug gene;
DGIdb 3.0: a redesign and expansion of the drug–gene interaction database
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1143
Abstract: Abstract The drug–gene interaction database (DGIdb, www.dgidb.org) consolidates, organizes and presents drug–gene interactions and gene druggability information from papers, databases and web resources. DGIdb normalizes content from 30 disparate sources and allows for user-friendly advanced… read more here.
Keywords: drug gene; dgidb; database; interaction ... See more keywords
Identifying the prevalence of clinically actionable drug‐gene interactions in a health system biorepository to guide pharmacogenetics implementation services
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DOI: 10.1111/cts.13449
Abstract: Understanding patterns of drug‐gene interactions (DGIs) is important for advancing the clinical implementation of pharmacogenetics (PGx) into routine practice. Prior studies have estimated the prevalence of DGIs, but few have confirmed DGIs in patients with… read more here.
Keywords: prevalence; drug gene; implementation; gene interactions ... See more keywords
Abstract 3098: Nanotherapeutics for combination drug and gene therapy in treating glioblastoma multiforme
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3098
Abstract: Gliomas represent approximately 80% of all malignant brain tumors, and glioblastoma multiforme (GBM), the most aggressive type, accounts for nearly half of all gliomas. Despite treatment strategies including surgery, radiation, and chemotherapy, the 5-year survival… read more here.
Keywords: drug gene; gbm; gene therapy; drug ... See more keywords
Evaluation of pharmacogenomic evidence for drugs related to ADME genes in CPIC database
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Personalized Therapy"
DOI: 10.1515/dmpt-2022-0123
Abstract: Abstract Objectives Clinical Pharmacogenetics Implementation Consortium (CPIC) is a platform that advances the pharmacogenomics (PGx) practice by developing evidence-based guidelines. The purpose of this study was to analyze the CPIC database for ADME related genes… read more here.
Keywords: gene; drug gene; cpic database; evidence ... See more keywords