Epidemiology of drug hypersensitivity reactions using 6-year national health insurance claim data from Korea
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-018-0625-9
Abstract: Background Drug hypersensitivity reactions (DHRs) constitute a large portion of adverse drug reactions (ADRs), but studies for DHR incidence based on national data are scarce. Objective This study aimed to estimate the incidence and patterns… read more here.
Keywords: incidence; insurance; year; drug ... See more keywords
Detection of drug-specific immunoglobulin E (IgE) and acute mediator release for the diagnosis of immediate drug hypersensitivity reactions.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2021.113101
Abstract: The diagnosis of a drug hypersensitivity reaction (DHR) is complex. The first step after taking the clinical history is to look for a sensitization to confirm or exclude the diagnosis and to identify the culprit… read more here.
Keywords: diagnosis; dhr; drug; drug hypersensitivity ... See more keywords
Diagnosis of drug causality in non-immediate drug hypersensitivity in children
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2018.1494570
Abstract: Drug hypersensitivity reactions are an important public health concern and are frequently suspected in children, with a selfreported prevalence of up to 6% [1]. Non-immediate drug hypersensitivity reactions are defined as drug reactions occurringmore than… read more here.
Keywords: non immediate; drug; reaction; drug hypersensitivity ... See more keywords
Genetic markers of drug hypersensitivity in pediatrics: current state and promise
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2022.2100345
Abstract: ABSTRACT Introduction Drug hypersensitivity reactions (DHRs) represent a great challenge to clinicians due to their unpredictability and severity, notably being potentially fatal. Genetic markers for DHRs have been emerging as potential valuable clinical tools for… read more here.
Keywords: genetic markers; markers drug; hypersensitivity pediatrics; drug ... See more keywords
Cutaneous drug hypersensitivity: developments and controversies.
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000548
Abstract: PURPOSE OF REVIEW Cutaneous drug hypersensitivity reactions (CDHRs) are a complicated area with multiple clinical manifestations and differential diagnoses, requiring differentiated diagnostic measurements and optimized therapeutic management. RECENT FINDINGS Disseminated CDHRs to classical drugs can… read more here.
Keywords: drug; cutaneous drug; developments controversies; drug hypersensitivity ... See more keywords
Pathology of T-cell-mediated drug hypersensitivity reactions and impact of tolerance mechanisms on patient susceptibility.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in allergy and clinical immunology"
DOI: 10.1097/aci.0000000000000834
Abstract: PURPOSE OF REVIEW T-cell-mediated drug hypersensitivity is responsible for significant morbidity and mortality, and represents a substantial clinical concern. The purpose of this article is to focus on T-cell reactions and discuss recent advances in… read more here.
Keywords: tolerance mechanisms; pathology; drug; drug hypersensitivity ... See more keywords
Drug hypersensitivity syndrome induced by sulfasalazine: A case report
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030060
Abstract: Introduction: Drug hypersensitivity syndrome (DHS) induced by sulfasalazine is a serious systemic delayed adverse drug reaction, which is associated with significant morbidity and mortality. Patient concerns: A 52-year-old man was hospitalized for developing a rash… read more here.
Keywords: hypersensitivity syndrome; case; induced sulfasalazine; drug ... See more keywords
Skin eruptions in children: Drug hypersensitivity vs viral exanthema
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Allergy and Immunology"
DOI: 10.1111/pai.13485
Abstract: Childhood rashes or exanthemas are common and are usually relatively benign. There are many causes of rash in children, including mainly viruses, and less often bacterial toxins, drugs, allergens and other diseases. Viral exanthema often… read more here.
Keywords: skin eruptions; drug; drug hypersensitivity; exanthema ... See more keywords
Delayed drug hypersensitivity reaction to secukinumab in a patient with hidradenitis suppurativa
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2022-249684
Abstract: A woman in her 30s presented to the dermatology clinic with widespread, pruritic, red papules and plaques involving the ears, trunk and extremities. The rash developed a few days after receiving her second injection of… read more here.
Keywords: reaction; hidradenitis suppurativa; drug hypersensitivity; hypersensitivity reaction ... See more keywords
An Update On the Immunological, Metabolic and Genetic Mechanisms in Drug Hypersensitivity Reactions.
Sign Up to like & getrecommendations! Published in 2019 at "Current pharmaceutical design"
DOI: 10.2174/1381612825666191105122414
Abstract: Drug hypersensitivity reactions (DHRs) represent a major burden on the healthcare system since their diagnostic and management are complex. As they can be influenced by individual genetic background, it is conceivably that the identification of… read more here.
Keywords: hypersensitivity reactions; drug; drug hypersensitivity; hypersensitivity ... See more keywords
Identification of Novel Biomarkers for Drug Hypersensitivity After Sequencing of the Promoter Area in 16 Genes of the Vitamin D Pathway and the High-Affinity IgE Receptor
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00582
Abstract: The prevalence of allergic diseases and drug hypersensitivity reactions (DHRs) during recent years is increasing. Both, allergic diseases and DHRs seem to be related to an interplay between environmental factors and genetic susceptibility. In recent… read more here.
Keywords: high affinity; pathway high; vitamin pathway; drug ... See more keywords