Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202513519
Abstract: Rhabdomyolysis, the breakdown of musculoskeletal tissue, can lead to life‐threatening complications such as rhabdomyolysis‐induced acute kidney injury (RI‐AKI), in which drug‐induced cases being the most common. Given the variability in the severity of drug‐induced adverse… read more here.
Keywords: drug induced; drug; rhabdomyolysis; kidney injury ... See more keywords
Multiscale Anisotropic Scaffold Integrating 3D Printing and Electrospinning Techniques as a Heart-on-a-chip Platform for Evaluating Drug-induced Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300719
Abstract: Cardiac safety assessments are significant in drug discovery, as drug-induced cardiotoxicity is the primary cause of drug attrition. Despite heart-on-a-chip technology having become an increasingly popular tool for evaluating drug-induced cardiotoxicity, its development remains a… read more here.
Keywords: drug induced; induced cardiotoxicity; cardiotoxicity; drug ... See more keywords
A Broad‐Spectrum ROS‐Eliminating Material for Prevention of Inflammation and Drug‐Induced Organ Toxicity
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Science"
DOI: 10.1002/advs.201800781
Abstract: Abstract Despite the great potential of numerous antioxidants for pharmacotherapy of diseases associated with inflammation and oxidative stress, many challenges remain for their clinical translation. Herein, a superoxidase dismutase/catalase‐mimetic material based on Tempol and phenylboronic… read more here.
Keywords: inflammation; drug induced; induced organ; broad spectrum ... See more keywords
Hierarchy‐Assembled Dual Probiotics System Ameliorates Cholestatic Drug‐Induced Liver Injury via Gut‐Liver Axis Modulation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200986
Abstract: Cholestatic drug‐induced liver injury (DILI) induced by drugs or other xenobiotics is a severe and even fatal clinical syndrome. Here, living materials of hierarchy‐assembled dual probiotics system are fabricated by sequentially encapsulating probiotic Lactobacillus delbrueckii… read more here.
Keywords: drug induced; gut; dili; cholestatic drug ... See more keywords
Drug‐induced hypersensitivity syndrome and eosinophils in skin biopsy in a patient with pancytopenia
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26742
Abstract: A 76-year-old man with acute myeloid leukemia (AML) presented to the Emergency Department with fever, a pruritic diffuse rash, and worsening painful oral ulcerations. Four days prior, the patient was initiated on low-dose cytarabine (LDAC)… read more here.
Keywords: drug induced; induced hypersensitivity; drug; hypersensitivity syndrome ... See more keywords
Lymphocyte profile and immune checkpoint expression in drug-induced liver injury: an immunophenotyping study.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2423
Abstract: The identification of specific human leukocyte antigen (HLA) risk alleles in drug-induced liver injury (DILI) points towards an important role of the adaptive immune system in DILI development. In this study we aimed to corroborate… read more here.
Keywords: immune checkpoint; induced liver; drug induced; liver injury ... See more keywords
Nusinerophages: Drug‐induced changes in cerebrospinal fluid
Sign Up to like & getrecommendations! Published in 2024 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25387
Abstract: Cytologic examination of the cerebrospinal fluid (CSF) is being performed in numerous clinical settings. One such scenario includes patients who receive intrathecal therapy. While this study is usually performed in oncology patients with the intent… read more here.
Keywords: nusinerophages drug; examination; drug induced; cerebrospinal fluid ... See more keywords
β‐Glucuronidase Inhibition in Drug Development: Emerging Strategies for Mitigating Drug‐Induced Toxicity and Enhancing Therapeutic Outcomes
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development Research"
DOI: 10.1002/ddr.70118
Abstract: β‐glucuronidase (βG) is a critical enzyme involved in the hydrolysis of glucuronide conjugates, significantly influencing drug metabolism, detoxification processes, and enterohepatic circulation. Although essential for maintaining physiological homeostasis, dysregulated βG activity has been implicated in… read more here.
Keywords: drug induced; induced toxicity; drug; toxicity ... See more keywords
Biomarkers of genome instability in normal mammalian genomes following drug‐induced replication stress
Sign Up to like & getrecommendations! Published in 2020 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22364
Abstract: Genome instability is a hallmark of most human cancers and is exacerbated following replication stress. However, the effects that drugs/xenobiotics have in promoting genome instability including chromosomal structural rearrangements in normal cells are not currently… read more here.
Keywords: drug induced; toxicology; genome instability; replication stress ... See more keywords
Microstructural white matter alterations in patients with drug induced parkinsonism
Sign Up to like & getrecommendations! Published in 2017 at "Human Brain Mapping"
DOI: 10.1002/hbm.23809
Abstract: Drug‐induced parkinsonism (DIP) is the second most common etiology of parkinsonism. And yet, there is little information on structural imaging in DIP to elucidate the accurate underlying pathomechanisms. To investigate microstructural white matter (WM) in… read more here.
Keywords: drug induced; dip; parkinsonism; microstructural white ... See more keywords
Prediction of Biochemical Nonresolution in Patients with Chronic Drug-induced Liver Injury: A Large Multicenter Study.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32283
Abstract: BACKGROUND AND AIMS To clarify high-risk factors and develop a novel nomogram model to predict biochemical resolution (BR) or not (BNR) in patients with chronic drug-induced liver injury (DILI). APPROACH AND RESULTS Retrospectively, 3,655 out… read more here.
Keywords: chronic drug; biochemical nonresolution; liver injury; patients chronic ... See more keywords