Multiscale Anisotropic Scaffold Integrating 3D Printing and Electrospinning Techniques as a Heart-on-a-chip Platform for Evaluating Drug-induced Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300719
Abstract: Cardiac safety assessments are significant in drug discovery, as drug-induced cardiotoxicity is the primary cause of drug attrition. Despite heart-on-a-chip technology having become an increasingly popular tool for evaluating drug-induced cardiotoxicity, its development remains a… read more here.
Keywords: drug induced; induced cardiotoxicity; cardiotoxicity; drug ... See more keywords
A Broad‐Spectrum ROS‐Eliminating Material for Prevention of Inflammation and Drug‐Induced Organ Toxicity
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DOI: 10.1002/advs.201800781
Abstract: Abstract Despite the great potential of numerous antioxidants for pharmacotherapy of diseases associated with inflammation and oxidative stress, many challenges remain for their clinical translation. Herein, a superoxidase dismutase/catalase‐mimetic material based on Tempol and phenylboronic… read more here.
Keywords: inflammation; drug induced; induced organ; broad spectrum ... See more keywords
Hierarchy‐Assembled Dual Probiotics System Ameliorates Cholestatic Drug‐Induced Liver Injury via Gut‐Liver Axis Modulation
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DOI: 10.1002/advs.202200986
Abstract: Cholestatic drug‐induced liver injury (DILI) induced by drugs or other xenobiotics is a severe and even fatal clinical syndrome. Here, living materials of hierarchy‐assembled dual probiotics system are fabricated by sequentially encapsulating probiotic Lactobacillus delbrueckii… read more here.
Keywords: drug induced; gut; dili; cholestatic drug ... See more keywords
Drug‐induced hypersensitivity syndrome and eosinophils in skin biopsy in a patient with pancytopenia
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26742
Abstract: A 76-year-old man with acute myeloid leukemia (AML) presented to the Emergency Department with fever, a pruritic diffuse rash, and worsening painful oral ulcerations. Four days prior, the patient was initiated on low-dose cytarabine (LDAC)… read more here.
Keywords: drug induced; induced hypersensitivity; drug; hypersensitivity syndrome ... See more keywords
Lymphocyte profile and immune checkpoint expression in drug-induced liver injury: an immunophenotyping study.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2423
Abstract: The identification of specific human leukocyte antigen (HLA) risk alleles in drug-induced liver injury (DILI) points towards an important role of the adaptive immune system in DILI development. In this study we aimed to corroborate… read more here.
Keywords: immune checkpoint; induced liver; drug induced; liver injury ... See more keywords
Biomarkers of genome instability in normal mammalian genomes following drug‐induced replication stress
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DOI: 10.1002/em.22364
Abstract: Genome instability is a hallmark of most human cancers and is exacerbated following replication stress. However, the effects that drugs/xenobiotics have in promoting genome instability including chromosomal structural rearrangements in normal cells are not currently… read more here.
Keywords: drug induced; toxicology; genome instability; replication stress ... See more keywords
Microstructural white matter alterations in patients with drug induced parkinsonism
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DOI: 10.1002/hbm.23809
Abstract: Drug‐induced parkinsonism (DIP) is the second most common etiology of parkinsonism. And yet, there is little information on structural imaging in DIP to elucidate the accurate underlying pathomechanisms. To investigate microstructural white matter (WM) in… read more here.
Keywords: drug induced; dip; parkinsonism; microstructural white ... See more keywords
Prediction of Biochemical Nonresolution in Patients with Chronic Drug-induced Liver Injury: A Large Multicenter Study.
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DOI: 10.1002/hep.32283
Abstract: BACKGROUND AND AIMS To clarify high-risk factors and develop a novel nomogram model to predict biochemical resolution (BR) or not (BNR) in patients with chronic drug-induced liver injury (DILI). APPROACH AND RESULTS Retrospectively, 3,655 out… read more here.
Keywords: chronic drug; biochemical nonresolution; liver injury; patients chronic ... See more keywords
Prediction of clinically relevant drug‐induced liver injury from structure using machine learning
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DOI: 10.1002/jat.3741
Abstract: Drug‐induced liver injury (DILI) is the most common cause of acute liver failure and often responsible for drug withdrawals from the market. Clinical manifestations vary, and toxicity may or may not appear dose‐dependent. We present… read more here.
Keywords: machine learning; liver injury; prediction clinically; drug induced ... See more keywords
In silico prediction of potential drug‐induced nephrotoxicity with machine learning methods
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DOI: 10.1002/jat.4331
Abstract: In recent years, drug‐induced nephrotoxicity has been one of the main reasons for the failure of drug development. Early prediction of the nephrotoxicity for drug candidates is critical to the success of clinical trials. Therefore,… read more here.
Keywords: drug induced; machine learning; prediction; drug ... See more keywords
Natural compounds against cytotoxic drug‐induced cardiotoxicity: A review on the involvement of PI3K/Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22683
Abstract: Cardiotoxicity is a critical concern in the use of several cytotoxic drugs. Induction of apoptosis, inflammation, and autophagy following dysregulation of the PI3K/Akt signaling pathway contributes to the cardiac damage induced by these drugs. Several… read more here.
Keywords: akt signaling; drug induced; pi3k akt; signaling pathway ... See more keywords