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Published in 2019 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2019.07.015
Abstract: Clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) systems have been employed as a powerful versatile technology for programmable gene editing, transcriptional modulation, epigenetic modulation, and genome labeling, etc. Yet better control of their…
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Keywords:
inducible crispr;
crispr cas;
drug inducible;
cas ... See more keywords
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Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16020-2
Abstract: Here, we describe a drug-inducible genetic system for insect sex-separation that demonstrates proof-of-principle for positive sex selection in D. melanogaster . The system exploits the toxicity of commonly used broad-spectrum antibiotics geneticin and puromycin to…
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Keywords:
insects;
sex;
sex separation;
drug inducible ... See more keywords