A Microbial Community Cultured in Gradient Hydrogel for Investigating Gut Microbiome‐Drug Interaction and Guiding Therapeutic Decisions
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202300977
Abstract: Despite the recognition that the gut microbiota acts a clinically significant role in cancer chemotherapy, both mechanistic understanding and translational research are still limited. Maximizing drug efficacy requires an in‐depth understanding of how the microbiota… read more here.
Keywords: efficacy; drug; drug interaction; gut microbiota ... See more keywords
A Phase 1, Open-Label, Fixed-Sequence, Drug-Drug Interaction Study of Zanubrutinib with Rifabutin in Healthy Volunteers.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1250
Abstract: Zanubrutinib is a second-generation Bruton tyrosine kinase inhibitor that is primarily metabolized by CYP3A enzymes. Previous drug-drug interaction (DDI) studies have demonstrated that co-administration of zanubrutinib with rifampin, a strong CYP3A inducer, reduces zanubrutinib plasma… read more here.
Keywords: open label; zanubrutinib; drug drug; phase open ... See more keywords
Evaluation of Drug-Drug Interaction Potential of Enarodustat (JTZ-951) Using a Cytochrome P450 Probe Cocktail.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1263
Abstract: The drug interaction potential of enarodustat (doses: 25, 50 mg) on the activity of cytochrome P450 (CYP) 1A2, 2C9, 2C19, 2D6, and 3A4 was evaluated after once-daily administration for 15 days in a phase 1 multiple-ascending-dose… read more here.
Keywords: interaction potential; day; enarodustat; drug interaction ... See more keywords
Prediction of the Impact of Cytochrome P450 2C9 Genotypes on the Drug–Drug Interaction Potential of Siponimod With Physiologically‐Based Pharmacokinetic Modeling: A Comprehensive Approach for Drug Label Recommendations
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1547
Abstract: We predicted the drug–drug interaction (DDI) potential of siponimod in presence of cytochrome P450 (CYP)2C9/CYP3A4 inhibitors/inducers in subjects with different CYP2C9 genotypes by physiologically‐based pharmacokinetic (PK) modeling. The model was established using in vitro and… read more here.
Keywords: siponimod; drug interaction; potential siponimod; drug ... See more keywords
Oral Glucose Tolerance Test: An Informative Endpoint or an Added Burden in Metformin Drug–Drug Interaction Studies?
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2650
Abstract: For drugs that inhibit organic cation transporters and/or multidrug and toxin extrusion proteins, a metformin clinical drug– drug interaction (DDI) study is recommended to assess the impact on metformin’s systemic exposure. An oral glucose tolerance… read more here.
Keywords: tolerance test; glucose tolerance; drug drug; oral glucose ... See more keywords
Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2891
Abstract: Oral formulations prepared from the leaves of the kratom (Mitragyna speciosa) plant are increasingly used for their opioid‐like effects to self‐manage opioid withdrawal and pain. Calls to US poison centers involving kratom exposures increased >50‐fold… read more here.
Keywords: interaction potential; kratom; drug interaction; natural product ... See more keywords
Understanding drug–drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-019-09626-7
Abstract: Here we characterize and summarize the pharmacokinetic changes for metabolized drugs when drug–drug interactions and pharmacogenomic variance are observed. Following multiple dosing to steady-state, oral systemic concentration–time curves appear to follow a one-compartment body model,… read more here.
Keywords: interaction pharmacogenomic; drug interaction; drug; concentration ... See more keywords
Drug Interaction With Sunitinib and the Evidence of Therapeutic Drug Monitoring: A Case Report and Review of the Literature
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Genitourinary Cancer"
DOI: 10.1016/j.clgc.2017.05.004
Abstract: Sunitinib has demonstrated efficacy, notably in metastatic renal cell carcinoma, but has also induced frequent diverse adverse events and has a large panel of drug interaction, notably with CYP 450. Sunitinib needs close monitoring for… read more here.
Keywords: drug; interaction sunitinib; drug monitoring; drug interaction ... See more keywords
Clustering based drug-drug interaction networks for possible repositioning of drugs against EGFR mutations: Clustering based DDI networks for EGFR mutations
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.04.011
Abstract: EGFRs are a vast group of receptor tyrosine kinases playing an important role in a number of tumors, including lungs, head and neck, breast, and esophageal cancers. A couple of techniques are being used in… read more here.
Keywords: egfr mutations; clustering based; drug interaction; drug ... See more keywords
A summary of the current drug interaction guidance from the European Medicines Agency and considerations of future updates.
Sign Up to like & getrecommendations! Published in 2020 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.11.005
Abstract: The current EMA drug interaction guideline was published in 2012. This guideline gives important recommendations on the information required to elucidate the interaction potential of an investigational drug, both as effects of the investigational drug… read more here.
Keywords: guideline; drug interaction; investigational drug; summary current ... See more keywords
Development and validation of an HPLC‐UV method for simultaneous determination of sildenafil and tramadol in biological fluids: Application to drug‐drug interaction study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2019.02.025
Abstract: Graphical abstract Figure. No caption available. HighlightsThe study describes a sensitive and selective HPLC coupled UV assay for determination of TMD and SDF in rabbit plasma.TMD increased Cmax, Tmax, AUC, and elimination rate constant (Kel)… read more here.
Keywords: drug interaction; study; drug; tmd sdf ... See more keywords