Safely Prescribing Nirmatrelvir and Ritonavir-Avoiding Drug-Drug Interactions.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2022.6834
Abstract: This Teachable Moment discusses drug-drug interactions with nirmatrelvir and ritonavir (Paxlovid) treatment for COVID-19 and considerations when prescribing. read more here.
Keywords: drug interactions; drug drug; nirmatrelvir ritonavir; safely prescribing ... See more keywords
Drug Interactions With Nirmatrelvir-Ritonavir in Older Adults Using Multiple Medications
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.20184
Abstract: This quality improvement study uses data from the MedSafer trial to evaluate drug-drug interactions between nirmatrelvir-ritonavir and maintenance medications to identify use of potentially inappropriate medications in older adults with polypharmacy. read more here.
Keywords: ritonavir older; older adults; drug interactions; nirmatrelvir ritonavir ... See more keywords
Association of polypharmacy and potential drug‐drug interactions with adverse treatment outcomes in older adults with advanced cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34642
Abstract: Polypharmacy is common in older adults who are starting cancer treatment and is associated with an increased risk of potentially inappropriate medications (PIMs) and potential drug‐drug interactions (PDIs). The authors evaluated the association of medication… read more here.
Keywords: potential drug; older adults; drug interactions; drug drug ... See more keywords
Drugs in COVID‐19 Clinical Trials: Predicting Transporter‐Mediated Drug‐Drug Interactions Using In Vitro Assays and Real‐World Data
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2236
Abstract: Numerous drugs are currently under accelerated clinical investigation for the treatment of coronavirus disease 2019 (COVID‐19); however, well‐established safety and efficacy data for these drugs are limited. The goal of this study was to predict… read more here.
Keywords: real world; drug interactions; drug; clinical trials ... See more keywords
Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2584
Abstract: This study was designed to assess the quantitative performance of endogenous biomarkers for organic anion transporting polypeptide (OATP) 1B1/1B3‐mediated drug‐drug interactions (DDIs). Ten healthy volunteers orally received OATP1B1/1B3 probe cocktail (0.2 mg pitavastatin, 1 mg… read more here.
Keywords: drug interactions; oatp1b1 1b3; pitavastatin; cysa ... See more keywords
An AI‐based Prediction Model for Drug‐drug Interactions in Osteoporosis and Paget's Diseases from SMILES
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Informatics"
DOI: 10.1002/minf.202100264
Abstract: The skeleton is one of the most important organs in the human body in assisting our motion and activities; however, bone density attenuates gradually as we age. Among common bone diseases are osteoporosis and Paget's,… read more here.
Keywords: drug interactions; drug drug; paget diseases; osteoporosis paget ... See more keywords
Prevalence of potential drug–drug interactions with disease‐specific treatments in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension: A registry study
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12114
Abstract: Abstract Polypharmacy increases the risk of drug–drug interactions that may disturb treatment effects. The aim of this study was to investigate the frequency of codispensing of potentially interacting or contraindicated drugs related to PH‐specific treatment… read more here.
Keywords: potential drug; hypertension; drug interactions; drug drug ... See more keywords
A super-combo-drug test to detect adverse drug events and drug interactions from electronic health records in the era of polypharmacy.
Sign Up to like & getrecommendations! Published in 2020 at "Statistics in medicine"
DOI: 10.1002/sim.8490
Abstract: Pharmacoinformatics research has experienced a great deal of successes in detecting drug-induced adverse events (AEs) using large-scale health record databases. In the era of polypharmacy, pharmacoinformatics faces many new challenges, and two significant challenges are… read more here.
Keywords: super combo; era polypharmacy; drug interactions; drug ... See more keywords
Robust causal inference of drug‐drug interactions
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9653
Abstract: There is growing interest in developing causal inference methods for multi‐valued treatments with a focus on pairwise average treatment effects. Here we focus on a clinically important, yet less‐studied estimand: causal drug‐drug interactions (DDIs), which… read more here.
Keywords: propensity score; causal inference; robust causal; drug interactions ... See more keywords
Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1554-6_3
Abstract: This chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug-drug interactions. read more here.
Keywords: drug interactions; enzyme inhibition; inhibition; irreversible enzyme ... See more keywords
CYP-associated drug-drug interactions: A mission accomplished?
Sign Up to like & getrecommendations! Published in 2020 at "Archives of toxicology"
DOI: 10.1007/s00204-020-02912-1
Abstract: On the basis of official Finnish Medicines Authority (Fimea)-approved drug monographs, less than half of the approved small-molecule drugs between 2007 and 2016 were substrates, inhibitors or inducers of CYP enzymes, predominantly of CYP3A4. No… read more here.
Keywords: drug interactions; drug; cyp associated; interactions mission ... See more keywords