Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A1 Receptor
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35266-x
Abstract: Despite intense interest in designing positive allosteric modulators (PAMs) as selective drugs of the adenosine A1 receptor (A1AR), structural binding modes of the receptor PAMs remain unknown. Using the first X-ray structure of the A1AR,… read more here.
Keywords: drug leads; binding modes; adenosine receptor; drug ... See more keywords
Drug Leads from Endophytic Fungi: Lessons Learned via Scaled Production.
Sign Up to like & getrecommendations! Published in 2020 at "Planta medica"
DOI: 10.1055/a-1130-4856
Abstract: Recently, the isolation and elucidation of a series of polyhydroxyanthraquinones were reported from an organic extract of a solid phase culture of an endophytic fungus, Penicillium restrictum (strain G85). One of these compounds, ω-hydroxyemodin (1:… read more here.
Keywords: drug leads; production; fungi lessons; endophytic fungi ... See more keywords
Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27134297
Abstract: Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for treatment of depression and other neurological disorders. Evidence has suggested that patients with atypical depression preferentially respond to natural product MAOIs. This review… read more here.
Keywords: potential new; natural products; drug leads; neurological disorders ... See more keywords