Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5243
Abstract: Choriocarcinoma is a rare and aggressive gynecological malignancy. The standard treatment is systemic chemotherapy as choriocarcinoma exhibits high chemosensitivity. However, refractory choriocarcinoma exhibits chemoresistance; thus, the prognosis remains very poor. This study aimed to identify… read more here.
Keywords: choriocarcinoma; drug library; novel therapeutic; library screening ... See more keywords
Evaluation of a Pooling Chemoproteomics Strategy with an FDA-Approved Drug Library.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00256
Abstract: Chemoproteomics is a key platform for characterizing the mode of action for compounds, especially for targeted protein degraders such as proteolysis targeting chimeras (PROTACs) and molecular glues. With deep proteome coverage, multiplexed tandem mass tag-mass… read more here.
Keywords: drug library; strategy; strategy fda; approved drug ... See more keywords
Antimicrobial compounds from an FDA-approved drug library with activity against Streptococcus suis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of applied microbiology"
DOI: 10.1111/jam.15377
Abstract: AIM Antimicrobial resistance (AMR) has become a global concern. Developing novel antimicrobials is one of the most effective approaches in tackling AMR. Considering its relatively low cost and risk, drug repurposing has been proposed as… read more here.
Keywords: antimicrobial compounds; approved drug; drug; fda approved ... See more keywords
O10 A quantitative and qualitative evaluation of the introduction of ‘smart’ syringe pumps into a paediatric intensive care unit
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-nppc.10
Abstract: Aim Infusion pumps are commonly used to administer medicines by intravenous infusion. Traditionally, pumps are programmed by simply entering the required number of millilitres (mL) per hour, and there has been no mechanism whereby the… read more here.
Keywords: infusion; drug; smart syringe; drug library ... See more keywords