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   Articles with "drug load" as a keyword



Site‐Specific Modification of Native IgGs with Flexible Drug‐Load

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recommendations! Published in 2024 at "Chembiochem"

DOI: 10.1002/cbic.202400511

Abstract: Homogeneous, site‐specifically conjugated antibodies have shown to result in antibody‐drug conjugates (ADCs) with improved efficacy and tolerability compared to stochastically conjugated ADCs. However, precisely controlling the drug load as well as attaching multiple payload moieties… read more here.

Keywords: antibody; modification native; site; drug ... See more keywords

Improving the Drug Load and in vitro Performance of Supersaturated Self-Nanoemulsifying Drug Delivery Systems (Super-SNEDDS) using Polymeric Precipitation Inhibitors.

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recommendations! Published in 2019 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2019.118960

Abstract: In this study, the influence of the polymeric precipitation inhibitor (PPI) PVP/VA 64 (polyvinylpyrrolidone-co-vinyl acetate) on the physical stability and in vitro performance of supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) containing the model drug simvastatin… read more here.

Keywords: super snedds; ppi; drug; performance ... See more keywords
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Degradation Rate Observations as a Function of Drug Load in Solid-State Drug Products.

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recommendations! Published in 2019 at "Journal of pharmaceutical sciences"

DOI: 10.1016/j.xphs.2018.12.003

Abstract: Degradation rates of solid-state drug products generally increase as the drug load decreases. A model for quantifying this effect based on surface area ratios is proposed here. This model relates the degradation rate to an… read more here.

Keywords: drug; degradation; degradation rate; drug load ... See more keywords

Dissolution Mechanisms of Amorphous Solid Dispersions: Role of Drug Load and Molecular Interactions.

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recommendations! Published in 2022 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.2c00892

Abstract: High drug load amorphous solid dispersions (ASDs) have been a challenge to formulate partially because drug release is inhibited at high drug loads. The maximum drug load prior to inhibition of release has been termed… read more here.

Keywords: polymer; amorphous solid; release; drug load ... See more keywords

Role of Fine Silica as Amorphous Solid Dispersion Carriers for Enhancing Drug Load and Preventing Recrystallization- A Comprehensive Review.

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recommendations! Published in 2022 at "Current drug delivery"

DOI: 10.2174/1567201819666220721111852

Abstract: Amorphous solid dispersion (ASD) is a popular concept for improving the dissolution and oral bioavailability of poorly water-soluble drugs. ASD faces two primary challenges of low drug loading and recrystallization upon storage. Several polymeric carriers… read more here.

Keywords: solid dispersion; amorphous solid; role; recrystallization ... See more keywords

Effects of Antiepileptic Drug Tapering on Episodic Memory as Measured by Virtual Reality Tests

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recommendations! Published in 2020 at "Frontiers in Neurology"

DOI: 10.3389/fneur.2020.00093

Abstract: Antiepileptic drugs impair episodic memory in patients with epilepsy, but this effect has so far only been examined with tests that do not provide first-person experience—an aspect that is crucial for episodic memory. Virtual reality… read more here.

Keywords: memory; drug; drug load; episodic memory ... See more keywords

Impact of Adjunctive VNS on Drug Load, Depression Severity, and Number of Neuromodulatory Maintenance Treatments

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recommendations! Published in 2024 at "Brain Sciences"

DOI: 10.3390/brainsci14020159

Abstract: Vagus nerve stimulation (VNS) is a long-term adjunctive treatment option in patients with difficult-to-treat depression (DTD). A total of n = 20 patients (mean age 52.6 years) were included in the multicenter, prospective, observational, naturalistic… read more here.

Keywords: depression; adjunctive vns; drug load; number ... See more keywords

Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

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recommendations! Published in 2021 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics13030430

Abstract: Affibody molecules hold great promise as carriers of cytotoxic drugs for cancer therapy due to their typically high affinity, easy production, and inherent control of the drug molecules’ loading and spatial arrangement. Here, the impact… read more here.

Keywords: drug conjugates; affibody; drug; effect ... See more keywords