Liquid Metal‐Enabled Microspheres with High Drug Loading and Multimodal Imaging for Artery Embolization
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202209413
Abstract: The drug‐eluting microspheres that have been widely used in clinical treatments such as chemoembolization commonly suffer from inadequate drug loading and tracking difficulties. With inherent high density and excellent biocompatibility, liquid metal (LM) has been… read more here.
Keywords: liquid metal; high drug; multimodal imaging; embolization ... See more keywords
Molecular Imprinting of Cyclodextrin Supramolecular Hydrogels Improves Drug Loading and Delivery.
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201800246
Abstract: Cyclodextrin-based controlled delivery materials have previously been developed for controlled release of different therapeutic drugs. In this study, a supramolecular hydrogel made from cyclodextrin-based macromonomers is subjected to molecular imprinting to investigate the impact on… read more here.
Keywords: drug loading; molecular imprinting; delivery; drug ... See more keywords
Two-Dimensional Ultra-Thin Nanosheets with Extraordinarily High Drug Loading and Long Blood Circulation for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200299
Abstract: Nanoparticle drug delivery is largely restricted by the low drug loading capacity of nanoparticle carriers. To address this critical challenge and maximize the potential of nanoparticle drug delivery, a 2D ultra-thin layered double hydroxide (LDH)… read more here.
Keywords: high drug; blood circulation; ultra thin; drug ... See more keywords
Preparation of a tumor-targeted drug-loading material, amphiphilic peptide P10, and analysis of its anti-tumor activity
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Materials Science: Materials in Medicine"
DOI: 10.1007/s10856-018-6204-8
Abstract: AbstractA new tumor-targeted drug-loading material, the amphiphilic peptide DGRGGGAAAA (P10) was designed and synthesized, and its self-assembly behavior, drug-loading effects and in vitro characteristics were studied. P10 was synthesized by solid-state synthesis and doxorubicin (DOX)… read more here.
Keywords: drug loading; drug; targeted drug; p10 ... See more keywords
Enhanced drug loading efficiency of contact lenses via salt-induced modulation
Sign Up to like & getrecommendations! Published in 2019 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2018.05.002
Abstract: Low drug loading efficiency is one of the main obstacles hindering the application of contact lenses (CLs) as the carrier for extended ocular drug delivery. Here in this study, a simple and effective drug loading… read more here.
Keywords: drug loading; salt; drug; loading efficiency ... See more keywords
Preparation, characterization, drug release and computational modelling studies of antibiotics loaded amorphous chitin nanoparticles.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.08.112
Abstract: We present a computational investigation of binding affinity of different types of drugs with chitin nanocarriers. Understanding the chitn polymer-drug interaction is important to design and optimize the chitin based drug delivery systems. The binding… read more here.
Keywords: drug loading; drug delivery; drug; chitin ... See more keywords
The role of sodium alginate on the supersaturation state of the poorly soluble drug chlorthalidone.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.01.007
Abstract: Solid dispersions (SDs) of chlorthalidone (CTD) are promising systems to enhance drug dissolution rate, generate and maintain drug supersaturation levels in gastrointestinal fluids. In this work, SDs of CTD were prepared by spray drying using… read more here.
Keywords: drug loading; role sodium; drug; sodium alginate ... See more keywords
Cellulose nanocrystals reinforced highly stretchable thermal-sensitive hydrogel with ultra-high drug loading.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.118122
Abstract: Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage. In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a… read more here.
Keywords: drug loading; sensitive hydrogel; thermal sensitive; stretchable thermal ... See more keywords
PEGylation of iron doped hydroxyapatite nanoparticles for increased applicability as MRI contrast agents and as drug vehicles: A study on thrombogenicity, cytocompatibility and drug loading
Sign Up to like & getrecommendations! Published in 2020 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2020.109934
Abstract: Abstract Contrast agents are heavily used in order to increase the accuracy of imaging based diagnostic techniques and since they are intravenously administrated, these agents need to be hemocompatible and cytocompatible. This work is a… read more here.
Keywords: hydroxyapatite nanoparticles; drug loading; contrast; doped hydroxyapatite ... See more keywords
A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.058
Abstract: A novel high drug loading pH-cleavable polymer hybrid nanoparticle was prepared via doxorubicin (DOX) grafted onto PEGylated, mussel-inspired polydopamine (PDA) and then coated onto hollow silica nanoparticles for drug delivery. A series of characterization shed… read more here.
Keywords: drug loading; novel high; drug delivery; drug ... See more keywords
Improved properties of fine active pharmaceutical ingredient powder blends and tablets at high drug loading via dry particle coating
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.04.002
Abstract: &NA; It has been shown that dry coating cohesive active pharmaceutical ingredients (APIs) with nano‐silica can improve packing and flow of their blends, facilitating high speed direct compression tableting. This paper examines the broader scope… read more here.
Keywords: drug loading; active pharmaceutical; nano silica; particle ... See more keywords