Multiscale modelling of drug mechanism and safety.
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DOI: 10.1016/j.drudis.2019.12.009
Abstract: Here, we introduce models at three levels (molecular level, cellular and omics level, and organ and system level) that study drug mechanism and safety in preclinical drug discovery. The models differ in both their scope… read more here.
Keywords: drug; multiscale modelling; mechanism safety; drug mechanism ... See more keywords
Drug mechanism‐of‐action discovery through the integration of pharmacological and CRISPR screens
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DOI: 10.15252/msb.20199405
Abstract: Low success rates during drug development are due, in part, to the difficulty of defining drug mechanism‐of‐action and molecular markers of therapeutic activity. Here, we integrated 199,219 drug sensitivity measurements for 397 unique anti‐cancer drugs… read more here.
Keywords: drug; sensitivity; mechanism action; drug mechanism ... See more keywords