Effect of the alkyl group in the piperazine N-substitution on the therapeutic action of rifamycins: A drug-membrane interaction study.
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DOI: 10.1016/j.cbi.2018.04.027
Abstract: In this work, we studied the effects of the N-alkyl group (methyl, cyclopentyl) in the piperazine ring of, respectively, rifampicin (RIF) and rifapentine (RPT) to correlate this substitution with their differential pharmacokinetic properties and overall… read more here.
Keywords: alkyl group; group; drug membrane; interaction ... See more keywords