Targeted Drug and Metabolite Imaging: Desorption Electrospray Ionization Combined with Triple Quadrupole Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2018 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.8b03857
Abstract: Mass spectrometry imaging (MSI) has proven to be a valuable tool for drug and metabolite imaging in pharmaceutical toxicology studies and can reveal, for example, accumulation of drug candidates in early drug development. However, the… read more here.
Keywords: desorption electrospray; mass spectrometry; metabolite imaging; drug ... See more keywords
Drug Metabolite Cluster-Based Data-Mining Method for Comprehensive Metabolism Study of 5-hydroxy-6,7,3′,4′-tetramethoxyflavone in Rats
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24183278
Abstract: The screening of drug metabolites in biological matrixes and structural characterization based on product ion spectra is among the most important, but also the most challenging due to the significant interferences from endogenous species. Traditionally,… read more here.
Keywords: data mining; metabolism; drug metabolites; drug ... See more keywords