Quantitative Proteomics of Hepatic Drug‐Metabolizing Enzymes and Transporters in Patients With Colorectal Cancer Metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2633
Abstract: The impact of liver cancer metastasis on protein abundance of 22 drug‐metabolizing enzymes (DMEs) and 25 transporters was investigated using liquid chromatography‐tandem accurate mass spectrometry targeted proteomics. Microsomes were prepared from liver tissue taken from… read more here.
Keywords: cancer metastasis; drug metabolizing; metabolizing enzymes; drug ... See more keywords
The effect of obesity, macronutrients, fasting and nutritional status on drug-metabolizing cytochrome P450s: a systematic review of current evidence on human studies
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nutrition"
DOI: 10.1007/s00394-020-02421-y
Abstract: Cytochrome P450s (CYPs) are a class of hemoproteins involved in drug metabolism. It has been reported that body composition, proportion of dietary macronutrients, fasting and nutritional status can interfere with the activity of drug-metabolizing CYPs.… read more here.
Keywords: drug metabolizing; macronutrients fasting; drug; nutritional status ... See more keywords
Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice?
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Nephrology"
DOI: 10.1007/s00467-018-4030-3
Abstract: CYP3A enzymes are involved in the metabolism of calcineurin inhibitor tacrolimus as well as vitamin D. In this review, we summarize the clinical aspects of CYP3A-mediated metabolism of tacrolimus and vitamin D with emphasis on… read more here.
Keywords: drug metabolizing; tacrolimus vitamin; enzymes cyp3a; metabolizing enzymes ... See more keywords
A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.01.012
Abstract: The flavon luteolin has various health-promoting activities including cardiovascular protection, anti-inflammatory activity and anticancer activity. A serum concentration of about 100 nM luteolin is reached by dietary habit. However, little is known about the function of… read more here.
Keywords: drug metabolizing; phase drug; physiological concentration; metabolizing enzymes ... See more keywords
mRNA levels of drug-metabolizing enzymes in 11 brain regions of cynomolgus macaques.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.12.003
Abstract: The cynomolgus macaque is an important nonhuman primate species in drug metabolism studies, in part because of its evolutionary closeness to humans. Cytochromes P450 (P450s) have been investigated in the major drug-metabolizing organs, i.e., the… read more here.
Keywords: drug metabolizing; enzymes brain; drug; brain regions ... See more keywords
Drug Metabolizing Enzyme and Transporter Genes Associated with Plasma Risperidone Level in Thai Autism Spectrum Disorder
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.02.196
Abstract: Background The associations between genetic variants of drug metabolizing enzyme and transporter (DMET) genes and steady-state plasma concentrations of risperidone, 9-hydroxyrisperidone, total active-moiety, and metabolic ratio remain unclear. Objective The objective of the present study… read more here.
Keywords: drug metabolizing; enzyme transporter; associated plasma; risperidone ... See more keywords
Expression of drug metabolizing enzymes and transporters in the cochlea: Implications for drug delivery and ototoxicity
Sign Up to like & getrecommendations! Published in 2019 at "Hearing Research"
DOI: 10.1016/j.heares.2019.05.002
Abstract: Inner ear drug delivery is a major area of research and development, but relatively little is known about basic drug metabolism in the cochlea. Additionally, the use of potentially ototoxic drugs such as NSAIDs, chemotherapeutics… read more here.
Keywords: drug metabolizing; drug delivery; drug; cochlea ... See more keywords
Nutritional modulation of intestinal drug-metabolizing cytochrome P450 by butyrate of different origin in chicken.
Sign Up to like & getrecommendations! Published in 2017 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2017.07.033
Abstract: Intestinal cytochrome P450 (CYP) enzymes play key role in the first pass metabolism of orally ingested xenobiotics, providing a primary metabolic barrier, being of special importance in maintaining animal health and production. This study was… read more here.
Keywords: different origin; drug metabolizing; butyrate; intestinal drug ... See more keywords
Characterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from A Quantitative, Activity and Selectivity Perspective
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DOI: 10.1038/s41598-019-45212-0
Abstract: Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism. Porcine CYP450 has… read more here.
Keywords: drug metabolizing; cyp450; drug; porcine ... See more keywords
Alterations of drug-metabolizing enzymes and transporters under diabetic conditions: what is the potential clinical significance?
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2018.1497645
Abstract: Abstract There will be 642 million people worldwide by 2040 suffering from diabetes mellitus. Long-term multidrug therapy aims to achieve normal glycemia and minimize complications, and avoid severe hypoglycemic events. The appreciation of the drug-metabolizing… read more here.
Keywords: drug metabolizing; drug; metabolizing enzymes; enzymes transporters ... See more keywords
Molecular modeling approaches to address drug-metabolizing enzymes (DMEs) mediated chemoresistance: a review
Sign Up to like & getrecommendations! Published in 2021 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2021.1874406
Abstract: Abstract Resistance against clinically approved anticancer drugs is the main roadblock in cancer treatment. Drug metabolizing enzymes (DMEs) that are capable of metabolizing a variety of xenobiotic get overexpressed in malignant cells, therefore, catalyzing drug… read more here.
Keywords: drug metabolizing; molecular modeling; chemoresistance; drug ... See more keywords