Prediction of Drug-Disease Associations for Drug Repositioning Through Drug-miRNA-Disease Heterogeneous Network
Sign Up to like & getrecommendations! Published in 2018 at "IEEE Access"
DOI: 10.1109/access.2018.2860632
Abstract: Drug repositioning, which refers to the identification of new clinical indications for existing drugs, has become an important strategy for drug discovery. The most recent studies in pharmacogenomics have demonstrated that drugs can target microRNAs… read more here.
Keywords: drug repositioning; drug mirna; disease associations; disease ... See more keywords
Combining non-negative matrix factorization with graph Laplacian regularization for predicting drug-miRNA associations based on multi-source information fusion
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1132012
Abstract: Increasing evidences suggest that miRNAs play a key role in the occurrence and progression of many complex human diseases. Therefore, targeting dysregulated miRNAs with small molecule drugs in the clinical has become a new treatment.… read more here.
Keywords: matrix; laplacian regularization; graph laplacian; non negative ... See more keywords