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Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25641
Abstract: Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is widely established for older generation AEDs, whereas there is limited evidence about newer AEDs. Our aim is to assess the benefit of TDM of newer generation…
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Keywords:
antiepileptic drugs;
therapeutic drug;
drug monitoring;
monitoring newer ... See more keywords
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Published in 2017 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.787
Abstract: Despite the fact that pharmacokinetic exposure of kinase inhibitors (KIs) is highly variable and clear relationships exist between exposure and treatment outcomes, fixed dosing is still standard practice. This review aims to summarize the available…
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Keywords:
kinase inhibitors;
therapeutic drug;
drug monitoring;
oncology ... See more keywords
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Published in 2018 at "Drug testing and analysis"
DOI: 10.1002/dta.2253
Abstract: A large variation in the levels of different ß-lactams and other antibiotics used in critically ill patients has been documented. The aim of this study is to establish and validate a fast, ultra-performance liquid chromatography-tandem…
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Keywords:
uplc method;
antibiotics used;
drug;
therapeutic drug ... See more keywords
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Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3243
Abstract: The collection of liquid biological matrices onto paper cards (Dried Matrix Spots - DMS) is becoming an alternative sampling strategy. The stability over time of molecules of interest for therapeutic, sport drug monitoring and forensic…
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Keywords:
drug monitoring;
individual identification;
drug;
dried urine ... See more keywords
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Published in 2021 at "Epilepsia Open"
DOI: 10.1002/epi4.12473
Abstract: Information to women with epilepsy on pregnancy‐related antiseizure medication (ASM) issues and reliable tools for therapeutic drug monitoring (TDM) are important aspects of epilepsy care. We aimed to develop and test an online tool for…
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Keywords:
information women;
pregnancy;
online tool;
women epilepsy ... See more keywords
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Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12653
Abstract: This study aimed to investigate the efficacy and tolerability of perampanel (PER) therapy and to optimize a specific plasma reference range for PER in children. Another major aim was to evaluate the potential determinators of…
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Keywords:
monitoring perampanel;
therapeutic drug;
concentration;
perampanel children ... See more keywords
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Published in 2021 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.1975
Abstract: Oritavancin and dalbavancin are long-acting lipoglycopeptides with activity against susceptible gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. Though similar in structure to traditional glycopeptide antibiotics like vancomycin, these antibiotics have terminal half-lives greater than 10 days,…
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Keywords:
vancomycin;
long acting;
therapeutic drug;
acting lipoglycopeptides ... See more keywords
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Published in 2017 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4300
Abstract: Research is needed to evaluate the impact of prescription drug monitoring programs (PDMPs). This paper describes research priorities for PDMPs that were initially discussed at a 2015 meeting of PDMP administrators, researchers, public health officials,…
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Keywords:
research;
monitoring programs;
drug;
prescription drug ... See more keywords
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Published in 2019 at "Der Nervenarzt"
DOI: 10.1007/s00115-018-0643-9
Abstract: Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood serum or plasma to optimize pharmacological therapy. TDM is an instrument with which the high interindividual variability of pharmacokinetics of patients…
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Keywords:
tdm task;
drug;
therapeutic drug;
tdm ... See more keywords
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Published in 2018 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-1349-3
Abstract: AbstractIn the clinic, ethosuximide is commonly used to treat generalized absence seizures but has recently been repurposed for other diseases. Because of adverse effects and drug interactions, high-throughput therapeutic drug monitoring of ethosuximide is necessary.…
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Keywords:
drug;
drug monitoring;
microextraction;
mass spectrometry ... See more keywords
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Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02253-4
Abstract: Although aripiprazole is one of the most used antipsychotics, knowledge about serum concentrations in children and adolescents is scarce and age-specific therapeutic ranges have not been established yet. Data of a routine therapeutic drug monitoring…
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Keywords:
serum concentrations;
treated aripiprazole;
therapeutic drug;
children adolescents ... See more keywords