Abnormal functional connectivity of the striatum in first‐episode drug‐naive early‐onset Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2535
Abstract: Abnormal brain network connectivity is strongly implicated in the pathogenesis of schizophrenia. The striatum, consisting of the caudate and putamen, is the major treatment target for antipsychotics, the primary treatments for schizophrenia; however, there are… read more here.
Keywords: connectivity; connectivity striatum; drug naive; functional connectivity ... See more keywords
Heterogeneous brain dynamic functional connectivity patterns in first‐episode drug‐naive patients with major depressive disorder
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26266
Abstract: It remains challenging to identify depression accurately due to its biological heterogeneity. As people suffering from depression are associated with functional brain network alterations, we investigated subtypes of patients with first‐episode drug‐naive (FEDN) depression based… read more here.
Keywords: connectivity; network; first episode; episode drug ... See more keywords
Genetic mechanisms underlying gray matter volume changes in patients with drug-naive first-episode schizophrenia.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebral cortex"
DOI: 10.1093/cercor/bhac211
Abstract: Brain structural damage is a typical feature of schizophrenia. Investigating such disease phenotype in patients with drug-naive first-episode schizophrenia (DFSZ) may exclude the confounds of antipsychotics and illness chronicity. However, small sample sizes and marked… read more here.
Keywords: naive first; first episode; drug naive; genetic mechanisms ... See more keywords
Machine Learning Classification of First-Onset Drug-Naive MDD Using Structural MRI
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DOI: 10.1109/access.2019.2949128
Abstract: It is hard to differentiate adolescent Major Depressive Disorder (MDD) patients from healthy adolescent controls based on structural MRI research findings, as the clinical characteristics of the patient group are heterogeneous, and the neuroimaging study… read more here.
Keywords: structural mri; first onset; onset drug; mdd ... See more keywords
Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s190268
Abstract: Background A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate… read more here.
Keywords: major depressive; study; mdd; integrity ... See more keywords
Correlations Between Working Memory Impairment and Neurometabolites of the Prefrontal Cortex in Drug-Naive Obsessive-Compulsive Disorder
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s296488
Abstract: Purpose This study aimed to investigate the mechanism of working memory (WM) impairment in drug-naive obsessive-compulsive disorder (OCD) by using neuropsychological tests and proton magnetic resonance spectroscopy (1H-MRS). Patients and Methods A total of 55… read more here.
Keywords: working memory; memory impairment; memory; ocd ... See more keywords
Once-Weekly Efpeglenatide Dose-Range Effects on Glycemic Control and Body Weight in Patients With Type 2 Diabetes on Metformin or Drug Naive, Referenced to Liraglutide
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes Care"
DOI: 10.2337/dc18-2648
Abstract: OBJECTIVE To explore the efficacy, safety, and tolerability of once-weekly efpeglenatide, a long-acting glucagon-like peptide 1 receptor agonist (GLP-1 RA), in early type 2 diabetes (T2D) (drug naive or on metformin monotherapy). RESEARCH DESIGN AND… read more here.
Keywords: efpeglenatide; weekly efpeglenatide; type diabetes; placebo ... See more keywords
A Meta-Analysis of Abnormal Glucose Metabolism in First-Episode Drug-Naive Schizophrenia.
Sign Up to like & getrecommendations! Published in 2020 at "Psychiatria Danubina"
DOI: 10.24869/psyd.2020.46
Abstract: BACKGROUND Patients with schizophrenia exhibit a higher mortality rate compared with the general population. This mortality has been attributed predominantly by the high risk of type 2 diabetes mellitus in the patients. We aimed to… read more here.
Keywords: schizophrenia; first episode; episode drug; glucose metabolism ... See more keywords
Classification of drug-naive children with attention-deficit/hyperactivity disorder from typical development controls using resting-state fMRI and graph theoretical approach
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Human Neuroscience"
DOI: 10.3389/fnhum.2022.948706
Abstract: Background and objectives The study of brain functional connectivity alterations in children with Attention-Deficit/Hyperactivity Disorder (ADHD) has been the subject of considerable investigation, but the biological mechanisms underlying these changes remain poorly understood. Here, we… read more here.
Keywords: naive children; brain; graph; drug naive ... See more keywords
Cerebral blood flow in adolescents with drug-naive, first-episode major depressive disorder: An arterial spin labeling study based on voxel-level whole-brain analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.966087
Abstract: Purpose The major depressive disorder (MDD) can be a threat to the health of people all over the world. Although governments have developed and implemented evidence-based interventions and prevention programs to prevent MDD and maintain… read more here.
Keywords: first episode; spin labeling; drug naive; depressive disorder ... See more keywords
Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2020.00098
Abstract: Abnormal functional connectivity (FC) within discrete brain networks is involved in the pathophysiology of obsessive-compulsive disorder (OCD) with inconsistent results. In the present study, we investigated the FC patterns of 40 drug-naive patients with OCD… read more here.
Keywords: network; compulsive disorder; obsessive compulsive; drug naive ... See more keywords