Drug nanocrystals for cancer therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1499
Abstract: Drug nanocrystals (NCs) with fascinating physicochemical properties have attracted great attention in drug delivery. High drug-loading efficiency, great structural stability, steady dissolution, and long circulation time are a few examples of these properties, which makes… read more here.
Keywords: drug; biology; drug nanocrystals; drug ncs ... See more keywords
Production of pure drug nanocrystals and nano co‐crystals by confinement methods☆
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Drug Delivery Reviews"
DOI: 10.1016/j.addr.2018.05.002
Abstract: ABSTRACT The use of drug nanocrystals in the drug formulation is increasing due to the large number of poorly water‐soluble drug compounds synthetized and due to the advantages brought by the nanonization process. The downsizing… read more here.
Keywords: nanocrystals nano; production pure; drug; pure drug ... See more keywords
Using Amphiphilic Polymer Micelles as the Templates of Antisolvent Crystallization to Produce Drug Nanocrystals
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01792
Abstract: Biocompatible and biodegradable amphiphilic polymeric micelles (PLA-CMCS-g-OA) were prepared by surface grafting of oleic acid and polylactic acid onto carboxymethyl chitosan and were used as templates for the crystallization of camptothecin. The camptothecin (CPT) nanocrystals… read more here.
Keywords: using amphiphilic; amphiphilic polymer; antisolvent crystallization; crystallization ... See more keywords
A carbohydrate polymer is a critical variable in the formulation of drug nanocrystals: a case study of idebenone
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2019.1682546
Abstract: ABSTRACT Objective: Stabilizers, especially carbohydrate polymers, have been shown to be necessary for the stabilization of drug nanocrystals. However, the impacts of select stabilizers on the in vitro and in vivo efficacy of therapeutics have… read more here.
Keywords: formulation drug; idbnc; study; drug ... See more keywords
Current strategies for oral delivery of BCS IV drug nanocrystals: challenges, solutions and future trends
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2021.1903428
Abstract: ABSTRACT Introduction Oral absorption of BCS IV drug benefits little from improved dissolution. Therefore, the absorption of BCS IV drug nanocrystals ‘as a whole’ strategy is preferred, and structural modification of nanocrystals is required. Surface… read more here.
Keywords: absorption; bcs drug; delivery; drug ... See more keywords
Drug Nanocrystals for Active Tumor-Targeted Drug Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14040797
Abstract: Drug nanocrystals, which are comprised of active pharmaceutical ingredients and only a small amount of essential stabilizers, have the ability to improve the solubility, dissolution and bioavailability of poorly water-soluble drugs; in turn, drug nanocrystal… read more here.
Keywords: targeted drug; tumor targeted; drug; drug nanocrystals ... See more keywords
Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for Oral Delivery of Quercetin
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14050897
Abstract: The aim of this study was to develop a new drug nanocrystals self-stabilized Pickering emulsion (NSSPE) for improving oral bioavailability of quercetin (QT). Quercetin nanocrystal (QT–NC) was fabricated by high pressure homogenization method, and QT–NSSPE… read more here.
Keywords: nanocrystals self; oral delivery; pickering emulsion; stabilized pickering ... See more keywords