Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes
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DOI: 10.1124/dmd.121.000742
Abstract: Many drug oxygenations are mainly mediated by polymorphic cytochromes P450 (P450s) and also by flavin-containing monooxygenases (FMOs). More than 50 years of research on P450/FMO-mediated drug oxygenations have clarified their catalytic roles. The natural product… read more here.
Keywords: drug metabolism; p450; drug; mediated polymorphic ... See more keywords