Human drug-pathway association prediction based on network consistency projection
Sign Up to like & getrecommendations! Published in 2022 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2022.107624
Abstract: We present a novel computational method for drug-pathway association prediction based on known drug-pathway associations. The association between a drug and a pathway needs to be examined to not only explain the cause and enable… read more here.
Keywords: drug; drug pathway; pathway association; network ... See more keywords
Drug-pathway association prediction: from experimental results to computational models
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa061
Abstract: Effective drugs are urgently needed to overcome human complex diseases. However, the research and development of novel drug would take long time and cost much money. Traditional drug discovery follows the rule of one drug-one… read more here.
Keywords: drug pathway; drug; pathway; pathway associations ... See more keywords
DPADM: a novel algorithm for detecting drug-pathway associations based on high-throughput transcriptional response to compounds
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac517
Abstract: Pathway genes functionally participate in the same biological process. They typically act cooperatively, and none is considered dispensable. The dominant paradigm in drug discovery is the one-to-one strategy, which aims to find the most sensitive… read more here.
Keywords: dpadm novel; drug pathway; novel algorithm; drug ... See more keywords
Construction of miRNA-regulated drug-pathway network to screen drug repurposing candidates for multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029107
Abstract: ABSTRACT Given the high disability rate of multiple sclerosis (MS), there is a need for safer and more effective therapeutic agents. Existing literature highlights the prominent roles of miRNA in MS pathophysiology. Nevertheless, there are… read more here.
Keywords: regulated drug; drug; mirna regulated; drug pathway ... See more keywords
Construction of an miRNA-regulated drug-pathway network reveals drug repurposing candidates for myasthenia gravis
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2017.2853
Abstract: Myasthenia gravis (MG) is a rare debilitating autoimmune neuromuscular disorder. Many studies have focused on the mechanism and treatment strategies of MG. However, the exact pathogenesis of MG and effective treatment strategies remain unclear. Recent… read more here.
Keywords: regulated drug; drug pathway; drug repurposing; drug ... See more keywords