A Dendritic Polymer‐Based Nanosystem Mediates Drug Penetration and Irreversible Endoplasmic Reticulum Stresses in Tumor via Neighboring Effect
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202201200
Abstract: Nanoparticles (NPs)‐based cancer therapeutics are generally impeded by poor drug penetration into solid tumors due to their dense tumor extracellular matrix (ECM). Herein, pH/redox‐responsive dendritic polymer‐based NPs are developed to amplify the neighboring effect for… read more here.
Keywords: effect; penetration; dendritic polymer; neighboring effect ... See more keywords
Ultrasound-Triggered Piezocatalysis for Selectively Controlled NO Gas and Chemodrug Release to Enhance Drug Penetration in Pancreatic Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c09948
Abstract: Nitric oxide (NO) is drawing widespread attention in treating pancreatic ductal adenocarcinoma (PDAC) as a safe and therapeutically efficient technique through modulating the dense fibrotic stroma in the tumor microenvironment to enhance drug penetration. Considerable… read more here.
Keywords: tumor; enhance drug; release; cpt ... See more keywords
Collagenase Nanoparticles Enhance the Penetration of Drugs Into Pancreatic Tumors.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.9b02395
Abstract: Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) limits drug penetration into the tumor and is associated with poor prognosis. Here, we demonstrate that a pretreatment based on a proteolytic-enzyme nanoparticle system, disassembles the… read more here.
Keywords: drug penetration; pdac; penetration; collagenase nanoparticles ... See more keywords
Recent advances in drug delivery systems for enhancing drug penetration into tumors
Sign Up to like & getrecommendations! Published in 2020 at "Drug Delivery"
DOI: 10.1080/10717544.2020.1831106
Abstract: Abstract The emergence of nanomaterials for drug delivery provides the opportunity to avoid the side effects of systemic drug administration and injury caused by the removal of tumors, delivering great promise for future cancer treatments.… read more here.
Keywords: drug penetration; penetration; drug delivery; drug ... See more keywords
Does Hyaluronidase Enhance Drug Penetration to Mechanoreceptors?
Sign Up to like & getrecommendations! Published in 2020 at "Skin Pharmacology and Physiology"
DOI: 10.1159/000510890
Abstract: Background: The pharmacological study of mechanoreceptors embedded within tissue is hampered by tissue barriers to applied research drugs. Methods: Hyaluronidase increases the permeability of tissues and is used clinically to facilitate the distribution of injected… read more here.
Keywords: drug penetration; hyaluronidase; penetration mechanoreceptors; hyaluronidase enhance ... See more keywords
Drug Penetration into the Central Nervous System: Pharmacokinetic Concepts and In Vitro Model Systems
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13101542
Abstract: Delivery of most drugs into the central nervous system (CNS) is restricted by the blood–brain barrier (BBB), which remains a significant bottleneck for development of novel CNS-targeted therapeutics or molecular tracers for neuroimaging. Consistent failure… read more here.
Keywords: drug penetration; nervous system; central nervous; drug ... See more keywords