In Vitro Skin Retention and Drug Permeation through Intact and Microneedle Pretreated Skin after Application of Propranolol Loaded Microemulsions
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DOI: 10.1007/s11095-018-2495-1
Abstract: PurposeTopical beta-blockers are efficacious for treating infantile hemangiomas, but no formulations have been specifically optimized for skin delivery. Our objective was to quantify skin concentrations and drug permeation of propranolol (a nonselective beta-blocker) after application… read more here.
Keywords: drug; skin concentrations; propranolol; drug permeation ... See more keywords
Formulation and Evaluation of Eudragit® RL Polymeric Double Layer Films for Prolonged-Release Transdermal Delivery of Tamsulosin Hydrochloride
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DOI: 10.1208/s12249-022-02358-x
Abstract: Transdermal drug delivery systems (TDDSs) were developed for prolonged tamsulosin (TMS) delivery. Double layer (DL) TDDSs were prepared using Eudragit® RL by conventional film-forming. Ethylene-vinyl acetate was used as the backing layer, triethylcitrate as plasticizer,… read more here.
Keywords: double layer; tamsulosin; drug permeation; drug ... See more keywords
Dermaplaning for Transdermal Drug Permeation Enhancement: A Qualitative and Quantitative Assessment
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DOI: 10.1208/s12249-023-02505-y
Abstract: In this study, we sought to investigate the effect of dermaplaning, a popular cosmeceutical skin rejuvenation technique on the permeation of drugs. Baclofen and diclofenac were used as hydrophilic and hydrophobic model drugs, respectively. A… read more here.
Keywords: permeation; dermaplaning transdermal; drug permeation; drug ... See more keywords
Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media
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DOI: 10.3390/pharmaceutics14040699
Abstract: The poor solubility and permeability of compounds beyond Lipinski’s Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of important questions… read more here.
Keywords: mucin; biorelevant media; permeability; drug permeation ... See more keywords
Three-Dimensional Oral Mucosal Equivalents as Models for Transmucosal Drug Permeation Studies
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DOI: 10.3390/pharmaceutics15051513
Abstract: Oral transmucosal administration, where drugs are absorbed directly through the non-keratinized, lining mucosa of the mouth, represents a solution to drug delivery with several advantages. Oral mucosal equivalents (OME) developed as 3D in vitro models… read more here.
Keywords: drug permeation; oral mucosal; mucosal; mucosal equivalents ... See more keywords
Design and evaluation of adhesive type transdermal patches of carvedilol
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DOI: 10.5958/0974-360x.2020.00867.7
Abstract: The transdermal adhesive patches of carvedilol were designed using pressure sensitive acrylic adhesives such as DUROTAK® 87-235A, DUROTAK® 87-8301 and DUROTAK® 87-4287. The patches were evaluated for physicochemical characterization, in-vitro drug permeation across dialysis membrane… read more here.
Keywords: adhesive type; patches carvedilol; drug permeation; formulation ... See more keywords