Gut microbiota modulates drug pharmacokinetics
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2018.1497647
Abstract: Abstract Gut microbiota, one of the determinants of pharmacokinetics, has long been underestimated. It is now generally accepted that the gut microbiota plays an important role in drug metabolism during enterohepatic circulation either before drug… read more here.
Keywords: drug; drug metabolism; gut microbiota; drug pharmacokinetics ... See more keywords
Effect of laparoscopic sleeve gastrectomy on drug pharmacokinetics.
Sign Up to like & getrecommendations! Published in 2021 at "Expert review of clinical pharmacology"
DOI: 10.1080/17512433.2021.1997585
Abstract: INTRODUCTION Given its feasibility and efficacy, laparoscopic sleeve gastrectomy (LSG) has become a widely accepted bariatric surgery for patients with clinically diagnosed severe obesity. LSG induces anatomical changes and subsequent weight loss which may affect… read more here.
Keywords: laparoscopic sleeve; sleeve gastrectomy; drug; effect ... See more keywords
Importance of Drug Pharmacokinetics at the Site of Action
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DOI: 10.1111/cts.12448
Abstract: Pharmacological activity depends on adequate drug levels at the effect site, but access to these sites for pharmacokinetic sampling is often limited. Thus, we often rely on plasma concentrations as surrogates in efforts to understand… read more here.
Keywords: pharmacokinetics site; drug; site; site action ... See more keywords
B‐cell repopulation dynamics and drug pharmacokinetics impact SARS‐CoV‐2 vaccine efficacy in anti‐CD20‐treated multiple sclerosis patients
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Neurology"
DOI: 10.1111/ene.15492
Abstract: Recent findings document a blunted humoral response to SARS‐CoV‐2 vaccination in patients on anti‐CD20 treatment. Although most patients develop a cellular response, it is still important to identify predictors of seroconversion to optimize vaccine responses. read more here.
Keywords: repopulation dynamics; anti cd20; dynamics drug; cell repopulation ... See more keywords
Harnessing Clinical Trial and Real-World Data Towards an Understanding of Sex Effects on Drug Pharmacokinetics, Pharmacodynamics and Efficacy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.874606
Abstract: Increasing clinical data on sex-related differences in drug efficacy and toxicity has highlighted the importance of understanding the impact of sex on drug pharmacokinetics and pharmacodynamics. Intrinsic differences between males and females, such as different… read more here.
Keywords: pharmacokinetics pharmacodynamics; harnessing clinical; sex; clinical trial ... See more keywords