Drug-Polymer Solubility Determination: A New Thermodynamic Model Free from Lattice Theory Assumptions
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Research"
DOI: 10.1007/s11095-019-2710-8
Abstract: Traditional methods for estimating drug-polymer solubility either require fast dissolution in the polymeric matrix, rapid re-crystallization kinetics from supersaturated states or derive from regular solution theories. In this work, we present a new method for… read more here.
Keywords: polymer solubility; drug polymer; drug; solubility ... See more keywords
A novel amorphous solid dispersion based on drug-polymer complexation.
Sign Up to like & getrecommendations! Published in 2020 at "Drug delivery and translational research"
DOI: 10.1007/s13346-020-00869-3
Abstract: Rafoxanide (RAF) is a poorly water-soluble drug that forms a complex with povidone K25 (PVP) in a cosolvent system containing acetone and an alkaline aqueous medium. This study aims to investigate the impact of RAF-PVP… read more here.
Keywords: raf; drug polymer; complexation; drug ... See more keywords
Rheological analysis of itraconazole‐polymer mixtures to determine optimal melt extrusion temperature for development of amorphous solid dispersion
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.10.034
Abstract: ABSTRACT The objective of this investigation was to develop a systematic method for the determination of optimal processing temperatures of drug‐polymer mixtures for the development of amorphous solid dispersion (ASD) by melt extrusion. Since melt… read more here.
Keywords: melt extrusion; drug polymer; polymer; drug ... See more keywords
Calculation of drug‐polymer mixing enthalpy as a new screening method of precipitation inhibitors for supersaturating pharmaceutical formulations
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2019.03.006
Abstract: ABSTRACT Supersaturating formulations are widely used to improve the oral bioavailability of poorly soluble drugs. However, supersaturated solutions are thermodynamically unstable and such formulations often must include a precipitation inhibitor (PI) to sustain the increased… read more here.
Keywords: precipitation; drug polymer; mixing enthalpy; polymer mixing ... See more keywords
Formulation of 3D Printed Tablet for Rapid Drug Release by Fused Deposition Modeling: Screening Polymers for Drug Release, Drug-Polymer Miscibility and Printability.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.10.021
Abstract: The primary aim of this study was to identify pharmaceutically acceptable amorphous polymers for producing 3D printed tablets of a model drug, haloperidol, for rapid release by fused deposition modeling. Filaments for 3D printing were… read more here.
Keywords: drug polymer; polymer; drug; drug release ... See more keywords
Elucidating the Molecular Mechanism of Drug-Polymer Interplay in a Polymeric Supersaturated System of Rifaximin.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c01022
Abstract: Supersaturated drug delivery system (SDDS) enables the solubility and sustained membrane transport of poorly water-soluble drugs. SDDS provides higher drug concentration in the dispersed phase and equilibrium in the continuous phase, which corresponds to amorphous… read more here.
Keywords: microscopy; drug polymer; drug; molecular mechanism ... See more keywords
Drug–Polymer Interactions in Acetaminophen/Hydroxypropylmethylcellulose Acetyl Succinate Amorphous Solid Dispersions Revealed by Multidimensional Multinuclear Solid-State NMR Spectroscopy
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00427
Abstract: The bioavailability of insoluble crystalline active pharmaceutical ingredients (APIs) can be enhanced by formulation as amorphous solid dispersions (ASDs). One of the key factors of ASD stabilization is the formation of drug–polymer interactions at the… read more here.
Keywords: polymer interactions; drug polymer; solid dispersions; drug ... See more keywords
Amorphous Drug–Polymer Salts: Maximizing Proton Transfer to Enhance Stability and Release
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00942
Abstract: An amorphous drug–polymer salt (ADPS) can be remarkably stable against crystallization at high temperature and humidity (e.g., 40°C/75% RH) and provide fast release. Here, we report that process conditions strongly influence the degree of proton… read more here.
Keywords: stability; salt formation; drug; drug polymer ... See more keywords
Rapid Nanogram Scale Screening Method of Microarrays to Evaluate Drug-Polymer Blends Using High-Throughput Printing Technology.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00182
Abstract: A miniaturized, high-throughput assay was optimized to screen polymer-drug solid dispersions using a 2-D Inkjet printer. By simply printing nanoliter amounts of polymer and drug solutions onto an inert surface, drug/polymer microdots of tunable composition… read more here.
Keywords: drug; drug polymer; scale; high throughput ... See more keywords
A New Method of Constructing a Drug-Polymer Temperature-Composition Phase Diagram Using Hot-Melt Extrusion.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00445
Abstract: Current experimental methodologies used to determine the thermodynamic solubility of an API within a polymer typically involves establishing the dissolution/melting end point of the crystalline API within a physical mixture or through the use of… read more here.
Keywords: temperature; drug polymer; thermodynamic solubility; drug ... See more keywords
Effect of variability of physical properties of povidone K30 on crystallization and drug-polymer miscibility of celecoxib-povidone K30 amorphous solid dispersion.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00452
Abstract: In the present study, we have investigated the variability in physical properties of povidone K30 (PVP K30) and its impact on crystallization and drug-polymer miscibility of celecoxib-PVP K30 (CLB-PVP K30) amorphous solid dispersions (ASDs). CLB-PVP… read more here.
Keywords: drug polymer; crystallization; polymer miscibility; miscibility ... See more keywords