Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis.
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DOI: 10.1021/acs.jmedchem.2c00589
Abstract: A novel approach for the dual inhibition of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1(17β HSD1) by a single drug was explored, starting from in-house 17β HSD1 inhibitors via masking their phenolic OH group… read more here.
Keywords: drug prodrug; steroid sulfatase; hydroxysteroid dehydrogenase; drug ... See more keywords