Intermittent treatment of BRAFV600E melanoma cells delays resistance by adaptive resensitization to drug rechallenge
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DOI: 10.1073/pnas.2113535119
Abstract: Significance Preclinical studies of metastatic melanoma treated with targeted therapeutics have suggested that alternating periods of treatment and withdrawal might delay the onset of resistance. This has been attributed to drug addiction, where cells lose… read more here.
Keywords: drug rechallenge; intermittent treatment; resistance; resensitization ... See more keywords