Drug repositioning in epilepsy reveals novel antiseizure candidates
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.703
Abstract: Epilepsy treatment falls short in ~30% of cases. A better understanding of epilepsy pathophysiology can guide rational drug development in this difficult to treat condition. We tested a low‐cost, drug‐repositioning strategy to identify candidate epilepsy… read more here.
Keywords: epilepsy; drug repositioning; epilepsy reveals; reveals novel ... See more keywords
Improvement of the performance of anticancer peptides using a drug repositioning pipeline.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology journal"
DOI: 10.1002/biot.202100417
Abstract: The use of anticancer peptides (ACPs) as an alternative/complementary strategy to conventional chemotherapy treatments has been shown to decrease drug resistance and/or severe side effects. However, the efficacy of the positively-charged ACP is inhibited by… read more here.
Keywords: drug repositioning; anticancer peptides; repositioning pipeline; drug ... See more keywords
Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia
Sign Up to like & getrecommendations! Published in 2019 at "Movement Disorders"
DOI: 10.1002/mds.27604
Abstract: Friedreich's ataxia is an autosomal‐recessive cerebellar ataxia caused by mutation of the frataxin gene, resulting in decreased frataxin expression, mitochondrial dysfunction, and oxidative stress. Currently, no treatment is available for Friedreich's ataxia patients. Given that… read more here.
Keywords: drug repositioning; friedreich ataxia; frataxin; ataxia ... See more keywords
Targeting multiple conformations of SARS-CoV2 Papain-Like Protease for drug repositioning: An in-silico study
Sign Up to like & getrecommendations! Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2021.104295
Abstract: Papain-Like Protease (PLpro) is a key protein for SARS-CoV-2 viral replication which is the cause of the emerging COVID-19 pandemic. Targeting PLpro can suppress viral replication and provide treatment options for COVID-19. Due to the… read more here.
Keywords: drug repositioning; targeting multiple; multiple conformations; like protease ... See more keywords
Drug repositioning: Progress and challenges in drug discovery for various diseases
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2022.114239
Abstract: Compared with traditional de novo drug discovery, drug repurposing has become an attractive drug discovery strategy due to its low-cost and high efficiency. Through a comprehensive analysis of the candidates that have been identified with… read more here.
Keywords: progress challenges; drug; repositioning progress; drug repositioning ... See more keywords
Evaluation of drug repositioning by molecular docking of pharmaceutical resources available in the Brazilian healthcare system against SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2021.100539
Abstract: In 2020 SARS-CoV-2 reached pandemic status, reaching Brazil in mid-February. As of now, no specific drugs for treating the disease are available. In this work, the possibility of interaction between SARS-CoV-2 viral proteins (open and… read more here.
Keywords: drug repositioning; system; evaluation drug; repositioning molecular ... See more keywords
Drug repositioning of TANK-binding kinase 1 inhibitor CYT387 as an alternative for the treatment of Gram-negative bacterial sepsis.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.05.051
Abstract: There is currently no specific drug for the treatment of sepsis and antibiotic administration is considered the best option, despite numerous issues. Therefore, the development of drugs to control the pathogen-induced inflammatory responses associated with… read more here.
Keywords: sepsis; tank binding; drug repositioning; inhibitor cyt387 ... See more keywords
EK-DRD: A Comprehensive Database for Drug Repositioning Inspired by Experimental Knowledge.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00365
Abstract: Drug repositioning, or the identification of new indications for approved therapeutic drugs, has gained substantial traction with both academics and pharmaceutical companies because it reduces the cost and duration of the drug development pipeline and… read more here.
Keywords: drug repositioning; drug; drd; database ... See more keywords
Drug repositioning for psychiatric and neurological disorders through a network medicine approach
Sign Up to like & getrecommendations! Published in 2020 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-0827-5
Abstract: Psychiatric and neurological disorders (PNDs) affect millions worldwide and only a few drugs achieve complete therapeutic success in the treatment of these disorders. Due to the high cost of developing novel drugs, drug repositioning represents… read more here.
Keywords: medicine; drug repositioning; psychiatric neurological; network medicine ... See more keywords
Literature-based prediction of novel drug indications considering relationships between entities.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00020k
Abstract: There have been many attempts to identify and develop new uses for existing drugs, which is known as drug repositioning. Among these efforts, text mining is an effective means of discovering novel knowledge from a… read more here.
Keywords: phenotype; phenotype associations; drug phenotype; drug repositioning ... See more keywords
Drug repositioning: current approaches and their implications in the precision medicine era
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Precision Medicine and Drug Development"
DOI: 10.1080/23808993.2018.1424535
Abstract: ABSTRACT Introduction: Drug repositioning implies finding new medical uses for existing drugs. It represents a cost-efficient approach, since the new indications are built on the basis of available information on pharmacokinetics, safety and manufacturing. Whereas… read more here.
Keywords: medicine; precision medicine; drug repositioning; era ... See more keywords