An Integrative Drug Repurposing Pipeline: Switching Viral Drugs to Breast Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25799
Abstract: The growing incidence rate of breast cancer, coupled with cellular chemotherapeutic resistance, has made this disease one of the most prevalent cancers among women worldwide. Despite the recent efforts to understand the underlying cause of… read more here.
Keywords: breast; drug repurposing; breast cancer; drug ... See more keywords
Target-based drug repurposing against Candida albicans-A computational modeling, docking, and molecular dynamic simulations study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30163
Abstract: The emergence of multidrug-resistant strains of Candida albicans has become a global threat mostly due to co-infection with immune-compromised patients leading to invasive candidiasis. The life-threatening form of the disease can be managed quickly and… read more here.
Keywords: drug repurposing; dynamic simulations; target; drug ... See more keywords
Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28693
Abstract: Cancer management is major concern of health organizations and viral cancers account for approximately 15.4% of all known human cancers. Due to large number of patients, efficient treatments for viral cancers are needed. De novo… read more here.
Keywords: machine learning; drug repurposing; deep learning; learning deep ... See more keywords
Drug repurposing approach to combating coronavirus: Potential drugs and drug targets
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Research Reviews"
DOI: 10.1002/med.21763
Abstract: In the past two decades, three highly pathogenic human coronaviruses severe acute respiratory syndrome coronavirus (SARS‐CoV), Middle East respiratory syndrome coronavirus, and, recently, SARS‐CoV‐2, have caused pandemics of severe acute respiratory diseases with alarming morbidity… read more here.
Keywords: approach combating; drug repurposing; combating coronavirus; drug ... See more keywords
Computational Methods for Drug Repurposing
Sign Up to like & getrecommendations! Published in 2019 at "Methods in Molecular Biology"
DOI: 10.1007/978-1-4939-8955-3
Abstract: Drug repurposing is a creative and resourceful approach to increase the number of therapies by exploiting available and approved drugs. However, identifying new protein targets for previously approved drugs is challenging. Although new strategies have… read more here.
Keywords: protein; drug repurposing; methods drug; drug ... See more keywords
Methods for Discovering and Targeting Druggable Protein-Protein Interfaces and Their Application to Repurposing.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8955-3_1
Abstract: Drug repurposing is a creative and resourceful approach to increase the number of therapies by exploiting available and approved drugs. However, identifying new protein targets for previously approved drugs is challenging. Although new strategies have… read more here.
Keywords: protein; drug repurposing; protein interfaces; drug ... See more keywords
Can Drug Repurposing be Effective Against Carbapenem-Resistant Acinetobacter baumannii?
Sign Up to like & getrecommendations! Published in 2021 at "Current Microbiology"
DOI: 10.1007/s00284-021-02693-5
Abstract: Carbapenem-resistant Acinetobacter baumannii has been classified as a top priority for the development of new therapies due to its resistance to most antibiotics. Drug repurposing may be a fast and inexpensive strategy for treating this… read more here.
Keywords: carbapenem resistant; carbapenem; acinetobacter baumannii; drug repurposing ... See more keywords
Drug repurposing using transcriptome sequencing and virtual drug screening in a patient with glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Investigational New Drugs"
DOI: 10.1007/s10637-020-01037-7
Abstract: Background Precision medicine and drug repurposing are attractive strategies, especially for tumors with worse prognosis. Glioblastoma is a highly malignant brain tumor with limited treatment options and short survival times. We identified novel BRAF (47-438del)… read more here.
Keywords: pik3r1 g376r; drug repurposing; drug; 438del pik3r1 ... See more keywords
Drug Repurposing: Claiming the Full Benefit from Drug Development
Sign Up to like & getrecommendations! Published in 2021 at "Current Cardiology Reports"
DOI: 10.1007/s11886-021-01484-5
Abstract: Drug development has evolved over the years from being one-at-a-time to be massive screens in an industrial manner. Bringing a new therapeutic agent from concept to bedside can take a decade and cost billions of… read more here.
Keywords: drug development; repurposing claiming; drug repurposing; drug ... See more keywords
Drug repurposing in cardiology
Sign Up to like & getrecommendations! Published in 2020 at "Netherlands Heart Journal"
DOI: 10.1007/s12471-020-01430-0
Abstract: In this month’s issue of the Netherlands Heart Journal, van de Bovenkamp et al. [1] describe their study design of the DoPING-HFpEF trial, a placebo-controlled cross-over trial that studies the effect of trimetazidine on diastolic… read more here.
Keywords: heart; cardiology; drug repurposing; trimetazidine ... See more keywords
Drug repurposing using computational methods to identify therapeutic options for COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Diabetes and Metabolic Disorders"
DOI: 10.1007/s40200-020-00546-9
Abstract: Purpose Recently, the world has been dealing with a new type of coronavirus called COVID-19 that in terms of symptoms is similar to the SARS coronavirus. Unfortunately, researchers could not find a registered therapy to… read more here.
Keywords: virtual screening; therapeutic options; drug repurposing; identify therapeutic ... See more keywords