Purposeful Drug Repurposing.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2025.0900
Abstract: This Viewpoint discusses a proposal to identify candidates for drug repurposing and allocate US Food and Drug Administration funds to cover the cost of evaluating and approving such drugs for their novel indications. read more here.
Keywords: drug repurposing; drug; purposeful drug;
Identification of novel anti‐leishmanials targeting glutathione synthetase of the parasite: a drug repurposing approach
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Letters"
DOI: 10.1002/1873-3468.15016
Abstract: Drug repurposing has emerged as an effective strategy against infectious diseases such as visceral leishmaniasis. Here, we evaluated four FDA‐approved drugs–valrubicin, ciclesonide, deflazacort, and telithromycin—for their anti‐leishmanial activity on Leishmania donovani parasites, especially their ability… read more here.
Keywords: drug repurposing; valrubicin ciclesonide; glutathione synthetase;
An Integrative Drug Repurposing Pipeline: Switching Viral Drugs to Breast Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25799
Abstract: The growing incidence rate of breast cancer, coupled with cellular chemotherapeutic resistance, has made this disease one of the most prevalent cancers among women worldwide. Despite the recent efforts to understand the underlying cause of… read more here.
Keywords: breast; drug repurposing; breast cancer; drug ... See more keywords
Target-based drug repurposing against Candida albicans-A computational modeling, docking, and molecular dynamic simulations study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30163
Abstract: The emergence of multidrug-resistant strains of Candida albicans has become a global threat mostly due to co-infection with immune-compromised patients leading to invasive candidiasis. The life-threatening form of the disease can be managed quickly and… read more here.
Keywords: drug repurposing; dynamic simulations; target; drug ... See more keywords
Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28693
Abstract: Cancer management is major concern of health organizations and viral cancers account for approximately 15.4% of all known human cancers. Due to large number of patients, efficient treatments for viral cancers are needed. De novo… read more here.
Keywords: machine learning; drug repurposing; deep learning; learning deep ... See more keywords
Drug Repurposing: In Vitro Evaluation of Simeprevir as a Novel Antiviral Drug Against Severe Fever With Thrombocytopenia Syndrome Virus
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70655
Abstract: Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), a tick‐borne virus with high mortality, currently lacks approved antiviral therapies. In this study, we evaluated the in vitro activity of 19 FDA‐approved drugs against a clinical isolate… read more here.
Keywords: drug repurposing; severe fever; drug; fever thrombocytopenia ... See more keywords
Drug repurposing approach to combating coronavirus: Potential drugs and drug targets
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Research Reviews"
DOI: 10.1002/med.21763
Abstract: In the past two decades, three highly pathogenic human coronaviruses severe acute respiratory syndrome coronavirus (SARS‐CoV), Middle East respiratory syndrome coronavirus, and, recently, SARS‐CoV‐2, have caused pandemics of severe acute respiratory diseases with alarming morbidity… read more here.
Keywords: approach combating; drug repurposing; combating coronavirus; drug ... See more keywords
Computational Methods for Drug Repurposing
Sign Up to like & getrecommendations! Published in 2019 at "Methods in Molecular Biology"
DOI: 10.1007/978-1-4939-8955-3
Abstract: Drug repurposing is a creative and resourceful approach to increase the number of therapies by exploiting available and approved drugs. However, identifying new protein targets for previously approved drugs is challenging. Although new strategies have… read more here.
Keywords: protein; drug repurposing; methods drug; drug ... See more keywords
Methods for Discovering and Targeting Druggable Protein-Protein Interfaces and Their Application to Repurposing.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8955-3_1
Abstract: Drug repurposing is a creative and resourceful approach to increase the number of therapies by exploiting available and approved drugs. However, identifying new protein targets for previously approved drugs is challenging. Although new strategies have… read more here.
Keywords: protein; drug repurposing; protein interfaces; drug ... See more keywords
Can Drug Repurposing be Effective Against Carbapenem-Resistant Acinetobacter baumannii?
Sign Up to like & getrecommendations! Published in 2021 at "Current Microbiology"
DOI: 10.1007/s00284-021-02693-5
Abstract: Carbapenem-resistant Acinetobacter baumannii has been classified as a top priority for the development of new therapies due to its resistance to most antibiotics. Drug repurposing may be a fast and inexpensive strategy for treating this… read more here.
Keywords: carbapenem resistant; carbapenem; acinetobacter baumannii; drug repurposing ... See more keywords
COVID-19 drug repurposing model based on pigeon-inspired optimizer and rough sets theory
Sign Up to like & getrecommendations! Published in 2024 at "Neural Computing and Applications"
DOI: 10.1007/s00521-024-09518-z
Abstract: Discovering the most effective anti-SARS-CoV-2 drugs is the optimal solution to get back to a normal life without COVID-19. Drug repurposing, also known as drug repositioning, has become one of the most important solutions for… read more here.
Keywords: drug repurposing; drug; covid drug; pigeon inspired ... See more keywords