Drug reservoir mechanism of Pt(II)-sulfur chelates based on pharmacokinetics of Pt(II) complex with thiols & thio-ethers: An experimental and theoretical approach
Sign Up to like & getrecommendations! Published in 2020 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2020.120202
Abstract: Abstract Dichloro Pt(II) complex, Cis-[Pt(AEP)Cl2], C-1 was synthesized with bidentate chelating ligand 1-(2-Aminoethyl)-pyrrolidine (AEP) and hydrolyzed to the corresponding complex [Pt(AEP)(OH2)2](ClO4)2, C-2 to investigate their pharmacokinetics and theoretical study. Bio-relevant tri-peptide glutathione (GSH) and amino… read more here.
Keywords: aep; sulfur; drug reservoir; mechanism ... See more keywords
An intracellular drug reservoir
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DOI: 10.1038/s41579-019-0241-2
Abstract: This study reports that lipid droplets provide a reservoir for a lipophilic tuberculosis drug and enhance drug efficacy. read more here.
Keywords: drug; microbiology; drug reservoir; intracellular drug ... See more keywords
Ruxolitinib-Loaded Imprinted Polymeric Drug Reservoir for the Local Management of Post-Surgical Residual Glioblastoma Cells
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DOI: 10.3390/polym15040965
Abstract: (1) Background: The current limitations of glioblastoma (GBM) chemotherapy were addressed by developing a molecularly imprinted polymer (MIP)-based drug reservoir designed for the localized and sustained release of ruxolitinib (RUX) within the tumor post-resection cavity,… read more here.
Keywords: drug reservoir; post surgical; drug release; release ... See more keywords