Nintedanib overcomes drug resistance from upregulation of FGFR signaling and imatinib-induced KIT mutations in gastrointestinal stromal tumors.
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DOI: 10.1002/1878-0261.13199
Abstract: Drug resistance remains a major challenge in the clinical treatment of gastrointestinal stromal tumors (GISTs). While acquired on-target mutations of mast/stem cell growth factor receptor (KIT) kinase is the major resistance mechanism, activation of alternative… read more here.
Keywords: imatinib; stromal tumors; kit mutations; resistance ... See more keywords
Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells
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DOI: 10.1002/1878-0261.13378
Abstract: Rab GTPase 3C (RAB3C) is a peripheral membrane protein that is involved in membrane trafficking (vesicle formation) and cell movement. Recently, researchers have noted the exocytosis of RAB proteins, and their dysregulation is correlated with… read more here.
Keywords: rab gtpase; resistance; drug resistance; rab3c ... See more keywords
Quenching Epigenetic Drug Resistance Using Anti-hypoxic Microparticles in Glioblastoma Patient-derived Chips.
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DOI: 10.1002/adhm.202102226
Abstract: Glioblastoma is one of the most intractable tumor types due to the progressive drug resistance upon tumor mass expansion. Incremental hypoxia inside the growing tumor mass drives epigenetic drug resistance by activating non-genetic repair of… read more here.
Keywords: drug; drug resistance; chip; epigenetic drug ... See more keywords
Intracellular Condensates of Oligopeptide for Targeting Lysosome and Addressing Multiple Drug Resistance of Cancer.
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DOI: 10.1002/adma.202104704
Abstract: Biomolecular condensates have been demonstrated as a ubiquitous phenomenon in biological systems and play a crucial role in controlling cellular functions. However, the spatiotemporal construction of artificial biomolecular condensates with functions remains challenging and has… read more here.
Keywords: biomolecular condensates; drug resistance; multiple drug; resistance ... See more keywords
Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications
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DOI: 10.1002/advs.202201609
Abstract: Extracellular vesicles (EVs) are cell‐derived nanosized vesicles that mediate cell‐to‐cell communication via transporting bioactive molecules and thus are critically involved in various physiological and pathological conditions. EVs contribute to different aspects of cancer progression, such… read more here.
Keywords: extracellular vesicles; cancer drug; resistance; cancer ... See more keywords
Genomic Landscape and Potential Regulation of RNA Editing in Drug Resistance
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DOI: 10.1002/advs.202207357
Abstract: Adenosine‐to‐inosine RNA editing critically affects the response of cancer therapies. However, comprehensive identification of drug resistance‐related RNA editing events and systematic understanding of how RNA editing mediates anticancer drug resistance remain unclear. Here, 7157 differential… read more here.
Keywords: rna editing; landscape potential; drug; drug resistance ... See more keywords
Vitamin K: A novel cancer chemosensitizer
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DOI: 10.1002/bab.2312
Abstract: Cancer incidences are growing rapidly and causing millions of deaths globally. Cancer treatment is one of the most exigent challenges. Drug resistance is a natural phenomenon and is considered one of the major obstacles in… read more here.
Keywords: cancer chemosensitizer; novel cancer; vitamin novel; cancer ... See more keywords
Flipping and other astonishing transporter dance moves in fungal drug resistance
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DOI: 10.1002/bies.202200035
Abstract: In all domains of life, transmembrane proteins from the ATP‐binding cassette (ABC) transporter family drive the translocation of diverse substances across lipid bilayers. In pathogenic fungi, the ABC transporters of the pleiotropic drug resistance (PDR)… read more here.
Keywords: transporter; resistance; astonishing transporter; flipping astonishing ... See more keywords
The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential
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DOI: 10.1002/cac2.12194
Abstract: Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises from the interaction of multiple factors including tobacco, alcohol consumption, and betel quid. Chemotherapeutic agents such as cisplatin, 5‐fluorouracil, and paclitaxel… read more here.
Keywords: drug; drug resistance; resistance oscc; oral squamous ... See more keywords
Identification of MAEL as a promoter for the drug resistance model of iPSCs derived from T‐ALL
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DOI: 10.1002/cam4.4712
Abstract: Significant progress has been made in the diagnosis and treatment of the drug‐resistant and highly recurrent refractory T cell acute lymphoblastic leukemia (T‐ALL). Primary tumor cell‐derived induced pluripotent stem cells (iPSCs) have become very useful… read more here.
Keywords: resistance; model; drug resistant; ipscs ... See more keywords
Exosomes and their roles in the chemoresistance of pancreatic cancer
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DOI: 10.1002/cam4.4830
Abstract: Pancreatic cancer (PC) remains one of the most lethal human malignancies worldwide. Due to the insidious onset and the rapid progression, most patients with PC are diagnosed at an advanced stage rendering them inoperable. Despite… read more here.
Keywords: pancreatic cancer; roles chemoresistance; exosomes roles; cancer ... See more keywords