Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2022.5648
Abstract: Importance Despite advances in the understanding of dietary therapies in children with drug-resistant epilepsy, no quantitative comparison exists between different dietary interventions. Objective To evaluate the comparative efficacy and safety of various dietary therapies in… read more here.
Keywords: dietary therapies; drug resistant; efficacy safety; epilepsy ... See more keywords
Interictal spike networks predict surgical outcome in patients with drug‐resistant focal epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51337
Abstract: To determine if properties of epileptic networks could be delineated using interictal spike propagation seen on stereo‐electroencephalography (SEEG) and if these properties could predict surgical outcome in patients with drug‐resistant epilepsy. read more here.
Keywords: predict surgical; surgical outcome; outcome patients; patients drug ... See more keywords
Assessing the role of rare genetic variants in drug‐resistant, non‐lesional focal epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51374
Abstract: Resistance to antiseizure medications (ASMs) is one of the major concerns in the treatment of epilepsy. Despite the increasing number of ASMs available, the proportion of individuals with drug‐resistant epilepsy remains unchanged. In this study,… read more here.
Keywords: epilepsy; role rare; genetic variants; drug resistant ... See more keywords
Drug‐resistant seizures associated with hyperinflammatory monocytes in FIRES
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DOI: 10.1002/acn3.51755
Abstract: Therapeutic strategies for patients with febrile infection‐related epilepsy syndrome (FIRES) are limited, ad hoc, and frequently ineffective. Based on evidence that inflammation drives pathogenesis in FIRES, we used ex vivo stimulation of peripheral blood mononuclear… read more here.
Keywords: associated hyperinflammatory; hyperinflammatory monocytes; monocytes fires; drug resistant ... See more keywords
Distinct plasma metabolomic signatures differentiate autoimmune encephalitis from drug‐resistant epilepsy
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.52112
Abstract: Differentiating forms of autoimmune encephalitis (AE) from other causes of seizures helps expedite immunotherapies in AE patients and informs studies regarding their contrasting pathophysiology. We aimed to investigate whether and how Nuclear Magnetic Resonance (NMR)‐based… read more here.
Keywords: autoimmune encephalitis; distinct plasma; resistant epilepsy; drug resistant ... See more keywords
Nuclei‐Specific Amygdala Enlargement Is Linked to Psychiatric Comorbidities in Drug‐Resistant Focal Epilepsy
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.70071
Abstract: Amygdala enlargement has been the subject of controversial studies regarding its significance in terms of pathogenicity both in epilepsy and in psychiatric comorbidities such as anxiety, depression, and post‐traumatic stress disorder. However, no causal link… read more here.
Keywords: focal epilepsy; resistant focal; drug resistant; psychiatric comorbidities ... See more keywords
Charge‐Convertible Degradable Nanocapsules for Eradication of Drug‐Resistant Large Tumors
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DOI: 10.1002/adfm.202502150
Abstract: Two major obstacles of nanomedicines in cancer therapy are the limited tumor penetrability and drug‐resistance, especially for those large tumors, severely hampering their therapeutic efficacy for clinical translation. Here, a charge‐convertible degradable silica nanocapsule co‐packaging… read more here.
Keywords: sipgp cap; drug; drug resistant; large tumors ... See more keywords
P-Glycoprotein Antibody Decorated Porous Hydrogel Particles for Capture and Release of Drug-Resistant Tumor Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900136
Abstract: Multidrug resistance is one of the leading causes of chemotherapy failure in cancer patients. Early detection and capture of drug-resistant tumor cells can facilitate the monitoring of the therapy process and improve the prognosis of… read more here.
Keywords: drug resistant; resistant tumor; tumor cells; hydrogel particles ... See more keywords
Microenvironment‐Adaptive Nanozyme for Accelerating Drug‐Resistant Bacteria‐Infected Wound Healing
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202596
Abstract: Reactive oxygen species (ROS) are favorable for antibacterial infection but their overproduction results in serious inflammatory response and aggravates the hypoxic state of the wound tissue, which is detrimental to healing stages of proliferation and… read more here.
Keywords: nanozyme; wound healing; bacteria infected; drug resistant ... See more keywords
Photothermal‐Driven α‐Amylase‐Modified Polydopamine Pot‐Like Nanomotors for Enhancing Penetration and Elimination of Drug‐Resistant Biofilms
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DOI: 10.1002/adhm.202403033
Abstract: Biological enzyme‐functionalized antibacterial nanoparticles, which can degrade biofilm and kill bacteria under mild reaction conditions, have attracted much attention for the elimination of deep‐seated bacterial infections. However, the poor diffusion and penetration capabilities of recently… read more here.
Keywords: deep seated; biofilms; photothermal driven; elimination ... See more keywords
Enhanced Photodynamic Therapy Synergizing with Neutrophil Recruitment Boosts Drug‐Resistant Bacterial Clearance
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DOI: 10.1002/adhm.202500232
Abstract: Antibiotic‐resistant bacteria produce some virulence factors as immune evasion molecules that interfere with a variety of innate immune defenses, which is associated with reduced levels of neutrophil recruitment. Antibiotics and neutrophils recruited by endogenous chemokines… read more here.
Keywords: photodynamic therapy; resistant bacteria; drug resistant; neutrophil recruitment ... See more keywords