Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2022.5648
Abstract: Importance Despite advances in the understanding of dietary therapies in children with drug-resistant epilepsy, no quantitative comparison exists between different dietary interventions. Objective To evaluate the comparative efficacy and safety of various dietary therapies in… read more here.
Keywords: dietary therapies; drug resistant; efficacy safety; epilepsy ... See more keywords
Interictal spike networks predict surgical outcome in patients with drug‐resistant focal epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51337
Abstract: To determine if properties of epileptic networks could be delineated using interictal spike propagation seen on stereo‐electroencephalography (SEEG) and if these properties could predict surgical outcome in patients with drug‐resistant epilepsy. read more here.
Keywords: predict surgical; surgical outcome; outcome patients; patients drug ... See more keywords
Assessing the role of rare genetic variants in drug‐resistant, non‐lesional focal epilepsy
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DOI: 10.1002/acn3.51374
Abstract: Resistance to antiseizure medications (ASMs) is one of the major concerns in the treatment of epilepsy. Despite the increasing number of ASMs available, the proportion of individuals with drug‐resistant epilepsy remains unchanged. In this study,… read more here.
Keywords: epilepsy; role rare; genetic variants; drug resistant ... See more keywords
Drug‐resistant seizures associated with hyperinflammatory monocytes in FIRES
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DOI: 10.1002/acn3.51755
Abstract: Therapeutic strategies for patients with febrile infection‐related epilepsy syndrome (FIRES) are limited, ad hoc, and frequently ineffective. Based on evidence that inflammation drives pathogenesis in FIRES, we used ex vivo stimulation of peripheral blood mononuclear… read more here.
Keywords: associated hyperinflammatory; hyperinflammatory monocytes; monocytes fires; drug resistant ... See more keywords
P-Glycoprotein Antibody Decorated Porous Hydrogel Particles for Capture and Release of Drug-Resistant Tumor Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900136
Abstract: Multidrug resistance is one of the leading causes of chemotherapy failure in cancer patients. Early detection and capture of drug-resistant tumor cells can facilitate the monitoring of the therapy process and improve the prognosis of… read more here.
Keywords: drug resistant; resistant tumor; tumor cells; hydrogel particles ... See more keywords
Microenvironment‐Adaptive Nanozyme for Accelerating Drug‐Resistant Bacteria‐Infected Wound Healing
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DOI: 10.1002/adhm.202202596
Abstract: Reactive oxygen species (ROS) are favorable for antibacterial infection but their overproduction results in serious inflammatory response and aggravates the hypoxic state of the wound tissue, which is detrimental to healing stages of proliferation and… read more here.
Keywords: nanozyme; wound healing; bacteria infected; drug resistant ... See more keywords
A Biomimetic Non-Antibiotic Approach to Eradicate Drug-Resistant Infections.
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DOI: 10.1002/adma.201806024
Abstract: The chronic infections by pathogenic Pseudomonas aeruginosa (P. aeruginosa) remain to be properly addressed. In particular, for drug-resistant strains, limited medication is available. An in vivo pneumonia model induced by a clinically isolated aminoglycoside resistant… read more here.
Keywords: non antibiotic; drug; drug resistant; approach eradicate ... See more keywords
An Electroluminodynamic Flexible Device for Highly Efficient Eradication of Drug‐Resistant Bacteria
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DOI: 10.1002/adma.202200334
Abstract: Photodynamic therapy (PDT) has attracted wide attention in antibacterial applications due to its advantages of spatial‐temporal selectivity, noninvasiveness, and low incidence to develop drug resistance. To make it more convenient, universal, and manipulatable for clinical… read more here.
Keywords: electroluminodynamic flexible; flexible device; drug resistant; resistant bacteria ... See more keywords
pH-Triggered Size-transformable and Bioactivity-switchable Self-assembling Chimeric Peptide Nano-assemblies for Combating Drug-Resistant Bacteria and Biofilms.
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DOI: 10.1002/adma.202210766
Abstract: Drug-resistant bacteria and biofilm-associated infections are prominent problems in the field of antibacterial medicine, seriously affecting human and animal health. Despite the great potential of nanomaterials in the antibacterial field, overcoming the paradox of size… read more here.
Keywords: chimeric peptide; peptide nano; self assembling; drug resistant ... See more keywords
CRISPR-based KCC2 upregulation attenuates drug-resistant seizure in mouse models of epilepsy.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of neurology"
DOI: 10.1002/ana.26656
Abstract: OBJECTIVE Precise intervention of K-Cl cotransporter isoform 2 (KCC2) as a promising target for drug-resistant epilepsy remains elusive. METHODS Here, we employed a CRISPRa system delivered by adeno-associated viruses (AAV) to specifically upregulate KCC2 in… read more here.
Keywords: epilepsy; kcc2 upregulation; seizure; drug resistant ... See more keywords
miR‐485's anti‐drug resistant epilepsy effects by regulating SV2A/PSD‐95 and targeting ABCC1 and neuronal signaling‐transduction proteins in hippocampus of rats
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2247
Abstract: Drug‐resistant epilepsy (DRE), most subsequently developing refractory epilepsy, causes a significant burden to the society. microRNAs have been demonstrated as key regulators and therapeutic targets in epilepsy. Accordingly, the aim of the present study was… read more here.
Keywords: epilepsy; mir 485; resistant epilepsy; drug resistant ... See more keywords