Dynamically Crosslinked Poly(ethylene‐glycol) Hydrogels Reveal a Critical Role of Viscoelasticity in Modulating Glioblastoma Fates and Drug Responses in 3D
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202147
Abstract: Glioblastoma multiforme (GBM) is the most prevalent and aggressive brain tumor in adults. Hydrogels have been employed as 3D in vitro culture models to elucidate how matrix cues such as stiffness and degradation drive GBM… read more here.
Keywords: viscoelasticity; drug responses; gbm; drug ... See more keywords
Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202103360
Abstract: Intratumor heterogeneity (ITH) stands as one of the main difficulties in the treatment of colorectal cancer (CRC) as it causes the development of resistant clones and leads to heterogeneous drug responses. Here, 12 sets of… read more here.
Keywords: cancer; tumor; drug; drug responses ... See more keywords
Hydrogel matrix presence and composition influence drug responses of encapsulated glioblastoma spheroids.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.05.005
Abstract: Glioblastoma multiforme (GBM) is the most aggressive brain tumor with median patient survival of 12-15 months. To facilitate treatment development, bioengineered GBM models that adequately recapitulate the in vivo tumor microenvironment are needed. Matrix-encapsulated multicellular… read more here.
Keywords: gbm spheroid; drug responses; hydrogel matrix; matrix ... See more keywords
A Microfluidic Chip-Based Automated System for Whole-Course Monitoring the Drug Responses of Organoids.
Sign Up to like & getrecommendations! Published in 2024 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c02075
Abstract: Tumor patients-derived organoids, as a promising preclinical prediction model, have been utilized to evaluate ex vivo drug responses for formulating optimal therapeutic strategies. Detecting adenosine triphosphate (ATP) has been widely used in existing organoid-based drug… read more here.
Keywords: system; drug responses; drug; whole course ... See more keywords
Combinatorial expression of GPCR isoforms affects signalling and drug responses
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2888-2
Abstract: G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology across human tissues in response to extracellular signals. GPCR-mediated signalling can differ because of changes in the sequence 1 , 2 or expression 3 of the… read more here.
Keywords: drug responses; combinatorial expression; gpcr isoforms; gpcr ... See more keywords
Assessment of the influence of body fat indices on antihypertensive drug responses
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.16265
Abstract: Less than 50% of patients treated for hypertension reach a target office systolic blood pressure (SBP). We aimed to evaluate the role of adiposity on antihypertensive drug responses in newly diagnosed hypertensive patients. read more here.
Keywords: influence body; drug responses; body fat; assessment influence ... See more keywords
An Immune-Related Genetic Feature Depicted the Heterogeneous Nature of Lung Adenocarcinoma and Squamous Cell Carcinoma and Their Distinctive Predicted Drug Responses
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8447083
Abstract: One of the primary causes of global cancer-associated mortality is lung cancer (LC). Current improvements in the management of LC rely mainly on the advancement of patient stratification, both molecularly and clinically, to achieve the… read more here.
Keywords: cell carcinoma; drug responses; lung adenocarcinoma; squamous cell ... See more keywords
BESTDR Enables Bayesian Quantification of Mechanism-Specific Drug Responses.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-25-1181
Abstract: Understanding drug responses at the cellular level is essential for elucidating mechanisms of action and advancing preclinical drug development. Traditional dose-response models rely on simplified metrics, limiting their ability to quantify parameters like cell division,… read more here.
Keywords: drug responses; response; mechanism specific; drug ... See more keywords
Endothelial-leukemia interactions remodel drug responses uncovering T-ALL vulnerabilities.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022015414
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and often incurable disease. To uncover therapeutic vulnerabilities, we first developed T-ALL patient-derived tumor-xenografts (PDX) and exposed PDX cells to a library of 433 clinical-stage compounds in… read more here.
Keywords: drug responses; interactions remodel; leukemia interactions; endothelial leukemia ... See more keywords
Certainty of genuine treatment increases drug responses among intellectually disabled patients
Sign Up to like & getrecommendations! Published in 2017 at "Neurology"
DOI: 10.1212/wnl.0000000000003934
Abstract: Objective: To determine the placebo component of treatment responses in patients with intellectual disability (ID). Methods: A statistical meta-analysis comparing bias-corrected effect sizes (Hedges g) of drug responses in open-label vs placebo-controlled clinical trials was… read more here.
Keywords: open label; drug responses; treatment; effect ... See more keywords
Myelin ensheathment and drug responses of oligodendrocytes are modulated by stiffness of artificial axons
Sign Up to like & getrecommendations! Published in 2025 at "PLOS ONE"
DOI: 10.1371/journal.pone.0290521
Abstract: Myelination is a key biological process wherein glial cells such as oligodendrocytes wrap myelin around neuronal axons, forming an insulative sheath that accelerates signal propagation down the axon. A major obstacle to understanding myelination is… read more here.
Keywords: drug responses; ensheathment drug; responses oligodendrocytes; myelin ensheathment ... See more keywords