Dynamically Crosslinked Poly(ethylene‐glycol) Hydrogels Reveal a Critical Role of Viscoelasticity in Modulating Glioblastoma Fates and Drug Responses in 3D
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202147
Abstract: Glioblastoma multiforme (GBM) is the most prevalent and aggressive brain tumor in adults. Hydrogels have been employed as 3D in vitro culture models to elucidate how matrix cues such as stiffness and degradation drive GBM… read more here.
Keywords: viscoelasticity; drug responses; gbm; drug ... See more keywords
Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202103360
Abstract: Intratumor heterogeneity (ITH) stands as one of the main difficulties in the treatment of colorectal cancer (CRC) as it causes the development of resistant clones and leads to heterogeneous drug responses. Here, 12 sets of… read more here.
Keywords: cancer; tumor; drug; drug responses ... See more keywords
Hydrogel matrix presence and composition influence drug responses of encapsulated glioblastoma spheroids.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.05.005
Abstract: Glioblastoma multiforme (GBM) is the most aggressive brain tumor with median patient survival of 12-15 months. To facilitate treatment development, bioengineered GBM models that adequately recapitulate the in vivo tumor microenvironment are needed. Matrix-encapsulated multicellular… read more here.
Keywords: gbm spheroid; drug responses; hydrogel matrix; matrix ... See more keywords
Combinatorial expression of GPCR isoforms affects signalling and drug responses
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2888-2
Abstract: G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology across human tissues in response to extracellular signals. GPCR-mediated signalling can differ because of changes in the sequence 1 , 2 or expression 3 of the… read more here.
Keywords: drug responses; combinatorial expression; gpcr isoforms; gpcr ... See more keywords
An Immune-Related Genetic Feature Depicted the Heterogeneous Nature of Lung Adenocarcinoma and Squamous Cell Carcinoma and Their Distinctive Predicted Drug Responses
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8447083
Abstract: One of the primary causes of global cancer-associated mortality is lung cancer (LC). Current improvements in the management of LC rely mainly on the advancement of patient stratification, both molecularly and clinically, to achieve the… read more here.
Keywords: cell carcinoma; drug responses; lung adenocarcinoma; squamous cell ... See more keywords
Endothelial-leukemia interactions remodel drug responses uncovering T-ALL vulnerabilities.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022015414
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and often incurable disease. To uncover therapeutic vulnerabilities, we first developed T-ALL patient-derived tumor-xenografts (PDX) and exposed PDX cells to a library of 433 clinical-stage compounds in… read more here.
Keywords: drug responses; interactions remodel; leukemia interactions; endothelial leukemia ... See more keywords
Certainty of genuine treatment increases drug responses among intellectually disabled patients
Sign Up to like & getrecommendations! Published in 2017 at "Neurology"
DOI: 10.1212/wnl.0000000000003934
Abstract: Objective: To determine the placebo component of treatment responses in patients with intellectual disability (ID). Methods: A statistical meta-analysis comparing bias-corrected effect sizes (Hedges g) of drug responses in open-label vs placebo-controlled clinical trials was… read more here.
Keywords: open label; drug responses; treatment; effect ... See more keywords
Analysis of variability in high throughput screening data: applications to melanoma cell lines and drug responses
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15347
Abstract: High-throughput screening (HTS) strategies and protocols have undergone significant development in the last decade. It is now possible to screen hundreds of thousands of compounds, each exploring multiple biological phenotypes and parameters, against various cell… read more here.
Keywords: melanoma cell; drug responses; cell lines; high throughput ... See more keywords
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202101320
Abstract: This work describes an optimized assay to determine CFTR drug responses in people with cystic fibrosis, using nasal-airway organoids that are generated from 2D differentiated epithelial monolayers. Cystic fibrosis is caused by genetic defects that… read more here.
Keywords: measuring cystic; drug responses; airway organoids; fibrosis ... See more keywords
Atrophy in the Left Amygdala Predicted Drug Responses in Idiopathic Generalized Epilepsy Patients With Tonic–Clonic Seizures
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.640016
Abstract: We aimed to determine the alterations in the subcortical structures of patients with idiopathic generalized epilepsy with tonic–clonic seizures (IGE-GTCS) via MRI volumetry and vertex-based shape analysis and to evaluate the relationships between MRI measures… read more here.
Keywords: idiopathic generalized; drug responses; tonic clonic; drug ... See more keywords
Three-Dimensional Ex Vivo Culture for Drug Responses of Patient-Derived Gastric Cancer Tissue
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.614096
Abstract: Gastric cancer (GC) is one of the most common malignancies with high mortality and substantial morbidity. Although the traditional treatment strategies for GC revolve around surgery, radiotherapy, and chemotherapy, none have been able to optimally… read more here.
Keywords: three dimensional; drug responses; gastric cancer; drug ... See more keywords