Gamma-hydroxybutyrate: is it a feasible alternative to midazolam in long-term mechanically ventilated children?
Sign Up to like & getrecommendations! Published in 2019 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2019.1618253
Abstract: Abstract Aim: Benzodiazepines like midazolam are commonly used for long-term sedation of critically ill children requiring mechanical ventilation. Tolerance to midazolam may occur in these patients resulting in a ceiling effect with insufficient or missing… read more here.
Keywords: ghb; drug rotation; long term; midazolam ... See more keywords
Fast drug rotation reduces bacterial resistance evolution in a microcosm experiment
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Evolutionary Biology"
DOI: 10.1111/jeb.14163
Abstract: Drug rotation (cycling), in which multiple drugs are administrated alternatively, has the potential for limiting resistance evolution in pathogens. The frequency of drug alternation could be a major factor to determine the effectiveness of drug… read more here.
Keywords: drug rotation; resistance evolution; drug;