An unbiased high‐throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12743
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading cause of cancer‐related deaths in the United States by 2020, due in part to innate resistance to widely used chemotherapeutic agents and limited knowledge… read more here.
Keywords: cancer; drug screen; gem; pdac ... See more keywords
A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2017.01.011
Abstract: Efforts to identify pharmaceuticals to treat heritable metabolic liver diseases have been hampered by the lack of models. However, cells with hepatocyte characteristics can be produced from induced pluripotent stem cells (iPSCs). Here, we have used hepatocyte-like… read more here.
Keywords: screen using; hepatocyte like; cardiac glycosides; like cells ... See more keywords
Rapid drug screen using 3D tumor organoids
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aar7507
Abstract: Breast cancer organoids enable high-throughput functional drug screens to potentially guide individualized therapy. Breast cancer organoids enable high-throughput functional drug screens to potentially guide individualized therapy. read more here.
Keywords: screen using; rapid drug; tumor organoids; drug ... See more keywords
Development and implementation of a clinician report to reduce unnecessary urine drug screen testing in the ED: a quality improvement initiative
Sign Up to like & getrecommendations! Published in 2021 at "Emergency Medicine Journal"
DOI: 10.1136/emermed-2020-210009
Abstract: Background Unnecessary testing is a problem-facing healthcare systems around the world striving to achieve sustainable care. Despite knowing this problem exists, clinicians continue to order tests that do not contribute to patient care. Using behavioural… read more here.
Keywords: urine drug; drug screen; audit feedback; feedback ... See more keywords
Mexiletine and False Positive Urine Drug Screen for Amphetamine: A Case Review
Sign Up to like & getrecommendations! Published in 2021 at "Case Reports in Medicine"
DOI: 10.1155/2021/7134394
Abstract: Advanced heart failure patients commonly suffer from ventricular arrhythmias which can be managed by antiarrhythmic drugs like mexiletine. These ventricular arrhythmias can be complicated by illicit drug use which alter outcomes and can potentially impact… read more here.
Keywords: positive urine; drug screen; drug; urine drug ... See more keywords