Recent Advances on cell Culture Platforms for in vitro Drug Screening and Cell Therapies: From Conventional to Microfluidic Strategies.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202202936
Abstract: The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical research based on biologically accurate screening approaches. Since establishing the 2D in vitro cell culture method, the scientific community has improved cell-based drug screening… read more here.
Keywords: drug screening; cell culture; cell; based microfluidics ... See more keywords
Recent advances in organ-on-chips integrated with bioprinting technologies for drug screening.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203172
Abstract: Currently the demand for more reliable drug screening devices has made scientists and researchers develop novel potential approaches to offer an alternative to animal studies. Organ-on-chips are newly emerged platforms for drug screening and disease… read more here.
Keywords: drug screening; organ chips; advances organ; drug ... See more keywords
3D printed human organoids: High throughput system for drug screening and testing in current COVID‐19 pandemic
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28166
Abstract: In the current pandemic, scenario the world is facing a huge shortage of effective drugs and other prophylactic medicine to treat patients which created havoc in several countries with poor resources. With limited demand and… read more here.
Keywords: drug screening; human organoids; printed human; screening testing ... See more keywords
High Throughput Confined Migration Microfluidic Device for Drug Screening.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207194
Abstract: Cancer metastasis is the major cause of cancer-related death. Excessive extracellular matrix deposition and increased stiffness are typical features of solid tumors, creating confined spaces for tumor cell migration and metastasis. Confined migration is involved… read more here.
Keywords: drug screening; confined migration; microfluidic device; migration ... See more keywords
Combined Effects of Electric Stimulation and Microgrooves in Cardiac Tissue-on-a-Chip for Drug Screening.
Sign Up to like & getrecommendations! Published in 2020 at "Small methods"
DOI: 10.1002/smtd.202000438
Abstract: Animal models and traditional cell cultures are essential tools for drug development. However, these platforms can show striking discrepancies in efficacy and side effects when compared to human trials. These differences can lengthen the drug… read more here.
Keywords: drug; drug screening; drug development; chip ... See more keywords
Vascular beds maintain pancreatic tumour explants for ex vivo drug screening
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2481
Abstract: Our understanding of cancer progression or response to therapies would benefit from benchtop, tissue‐level assays that preserve the biology and anatomy of human tumours ex vivo. We present a methodology for maintaining patient tumour samples… read more here.
Keywords: drug screening; methodology; tumour explants; tissue ... See more keywords
Drug Screening by Resazurin Colorimetry in Ewing Sarcoma.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1020-6_12
Abstract: In Ewing sarcoma (EwS), development of new therapeutic strategies is crucial in order to refine treatment and improve patient survival, especially in metastatic or recurrent disease stages. Thus, preclinical drug screening is a key issue… read more here.
Keywords: colorimetry; resazurin colorimetry; screening resazurin; drug screening ... See more keywords
Malignant ascites-derived organoid (MADO) cultures for gastric cancer in vitro modelling and drug screening
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-03004-z
Abstract: Malignant ascites (MA) is a common manifestation in advanced gastric cancer with peritoneal carcinomatosis and usually indicates a poor prognosis. However, lack of in vitro models that can faithfully recapitulate the characteristics of tumour cells… read more here.
Keywords: malignant ascites; gastric cancer; drug screening; vitro ... See more keywords
Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2227-7
Abstract: The successful identification of promising investigational therapies for the treatment of epilepsy can be credited to the use of numerous animal models of seizure and epilepsy for over 80 years. In this time, the maximal electroshock… read more here.
Keywords: epilepsy; validation preclinical; preclinical drug; pharmacoresistant ... See more keywords
Micrometastatic Drug Screening Platform Shows Heterogeneous Response to MAP Chemotherapy in Osteosarcoma Cell Lines
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Orthopaedics and Related Research"
DOI: 10.1007/s11999.0000000000000059
Abstract: Background Approximately 80% of patients with osteosarcoma harbor subclinical pulmonary micrometastases at diagnosis. Conventional chemotherapy includes methotrexate, doxorubicin, and cisplatin (MAP); however, this regimen and thus overall survival (60%-70%) have remained largely unchanged for 30… read more here.
Keywords: cell lines; osteosarcoma; map; drug screening ... See more keywords
Deep Learning Based Drug Screening for Novel Coronavirus 2019-nCov
Sign Up to like & getrecommendations! Published in 2020 at "Interdisciplinary Sciences, Computational Life Sciences"
DOI: 10.1007/s12539-020-00376-6
Abstract: A novel coronavirus, called 2019-nCoV, was recently found in Wuhan, Hubei Province of China, and now is spreading across China and other parts of the world. Although there are some drugs to treat 2019-nCoV, there… read more here.
Keywords: 2019 ncov; novel coronavirus; deep learning; drug ... See more keywords